920025-45-2

Upstream product

• 920025-43-0 C₁₄H₁₉FO₃ 
• 920025-41-8 C₃₄H₄₉FO₅ 
• 920025-40-7 C₄₀H₆₃FO₅Si 
• 860642-35-9 1-(4-fluorophenyl)but-3-en-2-one 
• 457948-95-7 2-(4-fluorophenyl)-N-methoxy-N-methylacetamide 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 405-50-5 p-Fluorophenylacetic acid 
• 849674-12-0 (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl-2,2,2-trichloroethanimidoate 
• 920025-44-1 C₂₀H₃₁FO₇S₂ 
• 1021816-97-6 C₁₄H₁₇FO₂ 

Relevant academic research and scientific papers

Use of NK-1 receptor antagonists in pruritus

The invention relates to methods for treating pruritus with an NK-1 receptor antagonist. The invention further relates to pharmaceutical compositions comprising NK-1 receptor antagonist.

POLYMORPHS OF A HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONIST

This application is directed to a novel polymorph of a hydroisoindoline tachykinin receptor antagonist having the following structural formula A.

Process for making hydroisoindoline tachykinin receptor antagonists

The present invention is directed to a process for preparing certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.