860779-35-7Relevant academic research and scientific papers
Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors
Edmondson, Scott D.,Mastracchio, Anthony,Duffy, Joseph L.,Eiermann, George J.,He, Huaibing,Ita, Ida,Leiting, Barbara,Leone, Joseph F.,Lyons, Kathryn A.,Makarewicz, Amanda M.,Patel, Reshma A.,Petrov, Aleksandr,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.
, p. 3048 - 3052 (2005)
anti-Substituted biaryl β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors that suffer from suboptimal selectivity and pharmacokinetics. This letter describes the substitution of the β-methyl substituent with β-polar subst
