Cas 860797-97-3,(1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-(3-methylbutyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

860797-97-3

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Basic information

Product Name: (1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-(3-methylbutyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide
Synonyms: (1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-(3-methylbutyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide
CAS NO:860797-97-3
Molecular Formula:
Molecular Weight: 670.679
EINECS: N/A
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Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-(3-methylbutyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide(CAS DataBase Reference)
NIST Chemistry Reference: (1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-(3-methylbutyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide(860797-97-3)
EPA Substance Registry System: (1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-(3-methylbutyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide(860797-97-3)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
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Hazardous Substances Data: 860797-97-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 860797-97-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,0,7,9 and 7 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 860797-97:
(8*8)+(7*6)+(6*0)+(5*7)+(4*9)+(3*7)+(2*9)+(1*7)=223
223 % 10 = 3
So 860797-97-3 is a valid CAS Registry Number.

860797-97-3Upstream product

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860797-97-3Relevant academic research and scientific papers

SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF

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Page/Page column 76-77, (2008/06/13)

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sens

Structure-based design of potent non-peptide MDM2 inhibitors

Ding, Ke,Lu, Yipin,Nikolovska-Coleska, Zaneta,Qiu, Su,Ding, Yousong,Gao, Wei,Stuckey, Jeanne,Krajewski, Krzysztof,Roller, Peter P.,Tomita, York,Parrish, Damon A.,Deschamps, Jeffrey R.,Wang, Shaomeng

, p. 10130 - 10131 (2007/10/03)

A successful structure-based design of a class of non-peptide small-molecule MDM2 inhibitors targeting the p53-MDM2 protein-protein interaction is reported. The most potent compound 1d binds to MDM2 protein with a Ki value of 86 nM and is 18 ti

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