86088-65-5

Upstream product

• 15544-49-7 N-(N⁴-p-toluenesulfonyl)-4-aminobutylphthalimide 
• 98-59-9 p-toluenesulfonyl chloride 
• 24697-70-9 N-(4-hydroxybutyl)phthalimide 
• 35517-18-1 N-(4-amino-1-butyl)phthalimide hydrochloride 
• 3184-61-0 4-phthalimidobutyronitrile 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 86101-33-9 N-<(4-(N-nitroso-p-toluenesulfonamido)-1-butyl)>phthalimide 

Downstream Products

• 5457-30-7 4-phthalimido-1-iodobutane 

Relevant academic research and scientific papers

COMPOUNDS AS HSP90 INHIBITORS

The invention provides novel compounds of formula (I) wherein: one of the a, b, c or d members is a nitrogen atom and the remaining members are carbon atoms; and R3 is a radical selected from the group consisting of: —S—R14 and —CH2—R15. The compounds of formula (I) are useful for treating diseases mediated by a heat shock protein 90 (Hsp 90)

Biosynthesis of streptothricin F. 5. Formation of β-lysine by Streptomyces L-1689-23

The formation of the β-lysine moiety of streptothricin F has been studied by feeding to Streptomyces L-1689-23 α-[3-13C,15N]-, α-[(3RS)-2H2]-, α-[(3R)-2H]-, and α[(3S)-2H]lysine and β-[(2S)-2H]lysine. From the analysis of either the 13C NMR or 2H NMR spectrum of the derived antibiotics, it has been determined that the α-nitrogen migrates to C-3 with inversion of configuration by an intramolecular process, and the 3-pro-R hydrogen migrates to C-2 with inversion of configuration by a process that is substantially or completely intermolecular. The very high degree of incorporation of labeled β-lysine indicates it is probably an intermediate in the biosynthesis of streptothricin F. The formation of the beta -lysine moiety of streptothricin F has been studied by feeding to Streptomyces L-1689-23 alpha - left bracket 3-**1**3C, **1**5N right bracket -, alpha - left bracket (3RS)-**2H//2 right bracket -, alpha - left bracket (3R)-**2H right bracket -, and alpha - left bracket (3S)-**2H right bracket lysine and beta - left bracket (2S)-**2H right bracket lysine. From the analysis of either the **1**3C NMR or **2H NMR spectrum of the derived antibotics, it has been determined that the alpha -nitrogen migrates to C-3 with inversion of configuration by an intramolecular process, and the 3-pro-R hydrogen migrates to C-2 with inversion of configuration by a process that is substantially or completely intermolecular. The very high degree of incorporation of labeled beta -lysine indicates it is probably an intermediate in the biosynthesis of streptothricin F.