86118-23-2Relevant academic research and scientific papers
Synthesis of 4,5,8-Eicosatrienoic Acids
Patterson, John W.,Pfister, Jurg R.,Wagner, Paul J.,Murthy, D. V. Krishna
, p. 2572 - 2576 (2007/10/02)
The synthesis of (7(tert-butyldimethylsiloxy)hepta-3,4-dien-1-yl)triphenylphosphonium iodide (1) is described.The ylide derived from 1 undergoes highly stereoselective Wittig reactions with aliphatic aldehydes to give a series of (7Z)-nonadeca-3,4,7-trien-1-ols (4) which were transformed into arachidonic acid analogues including (8Z,11Z,14Z)-eicosa-4,5,8,11,14-pentaenoic acid (9).
