86118-22-1

Upstream product

• 86118-38-9 cis-2-(2-chloroethyl)-1,1-dibromo-3-(2-(tert-butyldimethylsiloxy)ethyl)cyclopropane 
• 86118-39-0 7-chlorohepta-3,4-dien-1-yl tert-butyldimethylsilyl ether 
• 86118-35-6 6-hydroxy-3-hexyn-1-yl tert-butyldimethylsilyl ether 
• 86118-36-7 6-chloro-3-hexyn-1-yl tert-butyldimethylsilyl ether 
• 86118-37-8 (3Z)-6-chloro-3-hexen-1-yl tert-butyldimethylsilyl ether 
• 78592-82-2 4-(tert-butyldimethylsilyloxy)-1-butyne 
• 86118-40-3 7-iodohepta-3,4-dien-1-yl tert-butyldimethylsilyl ether 
• 603-35-0 triphenylphosphine 

Downstream Products

• 86118-23-2 [7-(tert-Butyl-dimethyl-silanyloxy)-hepta-3,4-dienylidene]-triphenyl-λ⁵-phosphane 

Relevant academic research and scientific papers

Synthesis of 4,5,8-Eicosatrienoic Acids

The synthesis of (7(tert-butyldimethylsiloxy)hepta-3,4-dien-1-yl)triphenylphosphonium iodide (1) is described.The ylide derived from 1 undergoes highly stereoselective Wittig reactions with aliphatic aldehydes to give a series of (7Z)-nonadeca-3,4,7-trien-1-ols (4) which were transformed into arachidonic acid analogues including (8Z,11Z,14Z)-eicosa-4,5,8,11,14-pentaenoic acid (9).