86129-63-7Relevant articles and documents
SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
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Page/Page column 44, (2009/04/24)
The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
An Easy and Convenient Synthesis of 6-Methyl-4(1H)-pyridone-3-carboxylic Acid
Mittelbach, Martin
, p. 479 - 480 (2007/10/02)
A new and easy synthesis of 6-methyl-4(1H)-pyridone-3-carboxylic acid (5), an important component of broad spectrum cephalosporins, is described.It starts from the readily available ethyl 4-hydroxy-6-methyl-2(1H)-pyridone-3-carboxylate (1), which is treated with phosphoryl chloride to give ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (2).Selective substitution of the chlorine in 4-position with alkoxide ion leads to the 4-alkoxypyridine derivatives 3.Hydrogenolysis of 3 affords ethyl 4-alkoxy-6-methyl-pyridine-3-carboxylates 4; which are hydrolysed to 5 in one step.