102266-59-1

Basic information

• Product Name: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-
• Synonyms: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-;4-amino-2-ethoxy-6-hydroxynicotinonitrile
• CAS NO: 102266-59-1
• Molecular Formula: C₈H₉N₃O₂
• Molecular Weight: 179.18
• Mol File: 102266-59-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-(102266-59-1)
• EPA Substance Registry System: 3-PYRIDINECARBONITRILE, 4-AMINO-2-ETHOXY-1,6-DIHYDRO-6-OXO-(102266-59-1)

Safety Data

• Hazardous Substances Data: 102266-59-1(Hazardous Substances Data)

Usage

General Description

The chemical 3-Pyridinecarbonitrile, 4-amino-2-ethoxy-1,6-dihydro-6-oxo- is a compound with the molecular formula C8H9N3O2. It is a derivative of 3-pyridinecarbonitrile, containing an amino group at the 4th position, an ethoxy group at the 2nd position, and a dihydro-6-oxo substituent. 3-Pyridinecarbonitrile, 4-amino-2-ethoxy-1,6-dihydro-6-oxo- may have potential applications in pharmaceutical research and drug development due to its unique structural features. It is important to handle and use this chemical with care, following proper safety protocols and guidelines to avoid any potential hazards.

Upstream product

• 141-52-6 sodium ethanolate 
• 86165-77-7 ethyl 3-amino-4,4-dicyanobut-3-enoate 

Downstream Products

• 904311-34-8 4-amino-5-cyano-6-ethoxy-N-[4-(methylsulfonyl)benzyl]pyridine-2-carboxamide 
• 904311-05-3 4-amino-N-[2-(aminosulfonyl)benzyl]-5-cyano-6-ethoxypyridine-2-carboxamide 

Relevant articles and documents

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors

C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK inhibitors could be valuable tools to study the therapeutic benefits of inhibiting these enzymes and as leads for potential drugs targeting JNKs. In this report, we disclose a series of potent and highly selective JNK inhibitors with good pharmacokinetic profiles.

Syntheses with Nitriles, LXXIV. - 3-Amino-4,4-dicyano-3-butenoate, a Synthetically Useful Dimer from Malononitrile and Cyanoacetate

An improved synthesis of 3-amino-4,4-dicyano-3-butenoate (4) (a codimer from cyanoacetate and malononitrile) is described.The 13C NMR data and pKa value of 4 are compared with those of the isomeric codimer 3 and the dimers 1 and 2.Reaction of 4 with acids or bases leads to the 2(1H)-pyridones 8 and 9, respectively.Conversions of 4 with aldehydes, ketones, and nitroso compounds give the products 11,14, and 15 as well as the benzopyran derivatives 12 and the 2-oxochinoline derivative 13 when using 2-hydroxy- and 2-aminobenzaldehydes. 4 reacts with formamidine to yield the dihydropyrimidine derivative 17 and with sulfur to give the 3,5-diamino-4-cyano-2-thiophenecarboxylates (18).