86169-29-1

Basic information

• Product Name: (2S)-Acetamido(4-chlorophenyl)acetic acid
• Synonyms: (S)-2-acetamido-2-(4-chlorophenyl)acetic acid
• CAS NO: 86169-29-1
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.644302
• Mol File: 86169-29-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2S)-Acetamido(4-chlorophenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-Acetamido(4-chlorophenyl)acetic acid(86169-29-1)
• EPA Substance Registry System: (2S)-Acetamido(4-chlorophenyl)acetic acid(86169-29-1)

Safety Data

• Hazardous Substances Data: 86169-29-1(Hazardous Substances Data)

Usage

General Description

(2S)-Acetamido(4-chlorophenyl)acetic acid, also known as Aceclofenac, is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. It works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. This makes it effective in the treatment of various conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Aceclofenac is available in oral tablet form and is commonly prescribed for the relief of pain and inflammation associated with these conditions. However, it should be used with caution and under the guidance of a healthcare professional due to potential side effects and interactions with other medications.

Upstream product

• 63327-49-1 N-acetyl-α-hydroxyglycine 
• 108-90-7 chlorobenzene 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 104-88-1 4-chlorobenzaldehyde 
• 1353886-52-8 2-(4-chlorophenyl)-2-(hydroxyimino)acetic acid 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 108-24-7 acetic anhydride 

Downstream Products

• 67336-19-0 (S)-2-amino-2-(4-chlorophenyl)acetic acid 

Relevant articles and documents

Convenient method for reduction of C-N double bonds in oximes, imines, and hydrazones using sodium Borohydride-Raney ni system

(Chemical Equation Presented) A practical method has been developed for reduction of C-N double bond in oximes, imines, and hydrazones with sodium borohydride catalyzed by Raney Ni. The reactions were carried out in basic aqueous solution, and the desired products were obtained in moderate yields after a simple procedure. This method can be applied to synthesize simpler aliphatic or aromatic amines and its analogs. Copyright Taylor & Francis Group, LLC.

Efficient chemoenzymatic synthesis of enantiomerically pure α-amino acids

A general two-step chemoenzymatic synthesis for enantiomerically pure natural and nonnatural α-amino acids is presented. In the first step of the sequence, the ubiquitous educts aldehyde, amide and carbon monoxide react by palladium-catalyzed amidocarbonylation to afford the racemic N-acyl amino acids in excellent yields. In the second step, enzymatic enantioselective hydrolysis yields the free optically pure a-amino acid and the other enantiomer as the N-acyl derivative, both in optical purities of 85-99.5% ee. The advantage of the chemoenzymatic process compared to other amino acid synthesis are demonstrated by the preparation of various functionalized (-OR, -Cl, -F, -SR) α-amino acids on a 10-g scale.