86176-44-5

Basic information

• Product Name: 2,3-Dihydro-2-methoxy-4H-1-benzopyran-4-one
• Synonyms: 2,3-Dihydro-2-methoxy-4H-1-benzopyran-4-one
• CAS NO: 86176-44-5
• Molecular Weight: 178.188
• Mol File: 86176-44-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,3-Dihydro-2-methoxy-4H-1-benzopyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-2-methoxy-4H-1-benzopyran-4-one(86176-44-5)
• EPA Substance Registry System: 2,3-Dihydro-2-methoxy-4H-1-benzopyran-4-one(86176-44-5)

Safety Data

• Hazardous Substances Data: 86176-44-5(Hazardous Substances Data)

Upstream product

• 60068-17-9 trimethyl<2-<1-<(trimethylsilyl)oxy>ethenyl>phenoxy>silane 
• 149-73-5 trimethyl orthoformate 
• 39079-62-4 chromone-3-carboxylic acid 
• 67-56-1 methanol 

Relevant articles and documents

Heteroannulation of 4-oxo-4H-1-benzopyrans (chromosomes) via the conjugate addition of haloalkanols in the presence of base

Chromones (4-oxo-4H-1-benzopyrans) bearing electron-withdrawing substituents at C-3 react with 2-haloethanols and potassium carbonate in acetone to produce tetrahydrofuro[2,3-b][1]benzopyran-4-ones, the heteroannulation proceeding via the conjugate addition of the haloethanol to the chromone, followed by intramolecular alkylation. Under the conditions of the reaction, the products derived from chromone-3-carbaldehydes undergo in situ deformylation.

Routes to Spiroacetals derived from Chroman-4-one

Methyl 2-(4'-hydroxybutyl)chromone-3-carboxylate (7) and the derived epoxide (13) undergo spirocyclisation on treatment with iodomethane-potassium carbonate and Lewis acid respectively.