861822-06-2

Upstream product

• 792921-69-8 (3S,4R,5E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide 
• 871236-67-8 1-((2S,3R,4S)-3,7-bis(tert-butyldimethylsilyloxy)-2,4-dimethylheptyloxy)methyl-4-methoxybenzene 
• 871236-53-2 ethyl (4S,5R,6S)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-4,6-dimethylheptanoate 
• 861821-97-8 ethyl (4S,5R,6S,2E)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-4,6-dimethylhept-2-enoate 
• 861821-98-9 (4S,5R,6S)-7-(methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-4,6-dimethylheptan-1-ol 
• 861821-96-7 (3S,4R,5S)-4,8-bis(tert-butyldimethylsilyloxy)-3,5-dimethyloct-1-yne 
• 861821-99-0 (2S,3R,4S)-3,7-bis(tert-butyldimethylsilyloxy)-2,4-dimethylheptan-1-ol 
• 861822-05-1 (4R,5S,10S,11R,12S,E)-5,11,15-tris(tert-butyldimethylsilyloxy)-4,10,12-trimethyl-1-trityloxypentadec-2-en-8-yn-7-one 

Downstream Products

• 861822-08-4 (4S,5R,6S,7Z,9S,11S,12R,13E)-5,9,11-tris(tert-butyldimethylsilyloxy)-4,6,12-trimethyl-15-(trityloxy)pentadeca-7,13-dien-1-ol 
• 861822-07-3 ((2E,4R,5S,7S,8Z,10S,11R,12S)-5,7,11,15-tetrakis(tert-butyldimethylsilyloxy)-4,10,12-trimethylpentadeca-2,8-dienyloxy)triphenylmethane 
• 861822-09-5 (2R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-one 
• 861822-02-8 (2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol 
• 861822-10-8 (4S,5S)-4-((2R,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-3,9,13,15-tetrakis(tert-butyldimethylsilyloxy)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-2-yl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxane 
• 861822-01-7 (2R,4E,8S,9R,10S,11Z,13S,15S,16R,17E)-9,15-bis(tert-butyldimethylsilyloxy)-13-(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-4,11,17-trien-3-one 
• 861822-00-6 (2E,4R,5S,7S,8Z,10S,11R,12S)-5,11,15-tris(tert-butyldimethylsilyloxy)-4,10,12-trimethyl-1-(trityloxy)pentadeca-2,8-dien-7-ol 

Relevant academic research and scientific papers

Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin

The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established through total synthesis of analogs followed by detailed biological characterization. A versatile synthetic strategy was used to prepare milligram quantities

ANALOGS OF DICTYOSTATIN, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF

Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and i

Synthesis and biological evaluation of (-)-16-normethyldictyostatin: A potent analogue of (-)-dictyostatin

(Chemical Equation Presented) (-)-16-Normethyldictyostatin has been made by total synthesis and is a potent antitumor agent in cells expressing wild-type tubulin and in one mutant cell line that is resistant to paclitaxel, but it is much less active than