861822-10-8

Upstream product

• 861822-02-8 (2S,3R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-ol 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 672296-45-6 {3(R)-[2(S)-(4-methoxyphenyl)-5(S)-methyl[1,3]dioxan-4(S)-yl]-2-oxobutyl}phosphonic acid dimethyl ester 
• 861822-01-7 (2R,4E,8S,9R,10S,11Z,13S,15S,16R,17E)-9,15-bis(tert-butyldimethylsilyloxy)-13-(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-4,11,17-trien-3-one 
• 861822-09-5 (2R,8S,9R,10S,11Z,13S,15S,16R,17E)-9,13,15-tris(tert-butyldimethylsilyloxy)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-8,10,16-trimethyl-19-(trityloxy)nonadeca-11,17-dien-3-one 
• 861822-07-3 ((2E,4R,5S,7S,8Z,10S,11R,12S)-5,7,11,15-tetrakis(tert-butyldimethylsilyloxy)-4,10,12-trimethylpentadeca-2,8-dienyloxy)triphenylmethane 
• 861822-08-4 (4S,5R,6S,7Z,9S,11S,12R,13E)-5,9,11-tris(tert-butyldimethylsilyloxy)-4,6,12-trimethyl-15-(trityloxy)pentadeca-7,13-dien-1-ol 
• 861822-00-6 (2E,4R,5S,7S,8Z,10S,11R,12S)-5,11,15-tris(tert-butyldimethylsilyloxy)-4,10,12-trimethyl-1-(trityloxy)pentadeca-2,8-dien-7-ol 
• 861822-06-2 (4R,5S,7S,10S,11R,12S,E)-5,11,15-tris(tert-butyldimethylsilyloxy)-4,10,12-trimethyl-1-(trityloxy)pentadec-2-en-8-yn-7-ol 
• 861822-05-1 (4R,5S,10S,11R,12S,E)-5,11,15-tris(tert-butyldimethylsilyloxy)-4,10,12-trimethyl-1-trityloxypentadec-2-en-8-yn-7-one 
• 792921-69-8 (3S,4R,5E)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N,4-dimethyl-7-(trityloxy)hept-5-enamide 
• 871236-67-8 1-((2S,3R,4S)-3,7-bis(tert-butyldimethylsilyloxy)-2,4-dimethylheptyloxy)methyl-4-methoxybenzene 
• 871236-53-2 ethyl (4S,5R,6S)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-4,6-dimethylheptanoate 
• 861821-97-8 ethyl (4S,5R,6S,2E)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-4,6-dimethylhept-2-enoate 

Downstream Products

• 861822-11-9 (2S,3S,4R,5R,10S,11R,12S,13Z,15S,17S,18R,19E)-3-(4-methoxybenzyloxy)-5,11,15,17-tetrakis(tert-butyldimethylsilyloxy)-2,4,10,12,18-pentamethyl-21-(trityloxy)henicosa-13,19-dien-1-ol 

Relevant academic research and scientific papers

Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin

The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established through total synthesis of analogs followed by detailed biological characterization. A versatile synthetic strategy was used to prepare milligram quantities

Synthesis and biological evaluation of (-)-16-normethyldictyostatin: A potent analogue of (-)-dictyostatin

(Chemical Equation Presented) (-)-16-Normethyldictyostatin has been made by total synthesis and is a potent antitumor agent in cells expressing wild-type tubulin and in one mutant cell line that is resistant to paclitaxel, but it is much less active than