70132-91-1

Upstream product

• 1313365-16-0 (2-Chloro-5-nitro-phenyl)-(4-chloro-phenyl)-methanol 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 108-90-7 chlorobenzene 

Downstream Products

• 381194-97-4 (4-Chloro-phenyl)-(5-nitro-2-piperidin-1-yl-phenyl)-methanone 
• 113456-83-0 [2-(4-hydroxy-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone 
• 113456-88-5 [2-(4-Butyl-piperidin-1-yl)-5-nitro-phenyl]-(4-chloro-phenyl)-methanone 
• 86187-85-1 [2-(4-methyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone 
• 113456-89-6 (4-Chloro-phenyl)-[5-nitro-2-(4-phenyl-piperidin-1-yl)-phenyl]-methanone 
• 113456-82-9 [2-(4-benzyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone 
• 113456-87-4 (4-Chloro-phenyl)-[2-(4-ethyl-piperidin-1-yl)-5-nitro-phenyl]-methanone 
• 113456-86-3 [2-(4-tert-Butyl-piperidin-1-yl)-5-nitro-phenyl]-(4-chloro-phenyl)-methanone 
• 70132-92-2 3-(4-chloro-phenyl)-5-nitro-benzo[d]isothiazole 
• 113456-77-2 [2-(2-methyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone 
• 113456-73-8 [2-(3-methyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone 
• 197653-93-3 (4-Chloro-phenyl)-(2-morpholin-4-yl-5-nitro-phenyl)-methanone 
• 197654-12-9 1-[2-(4-Chloro-benzoyl)-4-nitro-phenyl]-piperidine-3-carboxylic acid amide 
• 86188-01-4 4-chloro-2'-(4-methyl-1-piperidinyl)benzophenone 

Relevant academic research and scientific papers

Substituted Isoquinolinones and Quinazolinones

The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

PROCESS FOR THE PREPARATION OF 6-(PERFLUOROALKYL)URACIL COMPOUNDS FROM CARBAMATE COMPOUNDS

An improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having structural formula (I) from carbamate compounds having structural formula (II).

Synthesis and antitumor activity of novel benzophenone derivatives

Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.

(Benzoylphenyl)piperidines: A new class of immunomodulators

A series of (benzoylphenyl)piperidines has been synthesized and evaluated for activity as immunomodulators. Several of these compounds show good activity in primary screening on the basis of the lymphocytes mitogenic response to Con A, PHA, and PWM. A chloro group in position 4 of the benzoyl moiety as well as an amino group (or a carbamate derivative) para to the piperidine nucleus seems to be essential for activity. The depicted compounds may be considered as the first examples of a new series of immunomodulators.