70132-91-1Relevant articles and documents
Substituted Isoquinolinones and Quinazolinones
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Page/Page column 84, (2011/10/10)
The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
Synthesis and antitumor activity of novel benzophenone derivatives
Kumazawa, Eiji,Hirotani, Kenji,Burford, S. Clifford,Kawagoe, Keiichi,Miwa, Tamotsu,Mitsui, Ikuo,Ejima, Akio
, p. 1470 - 1474 (2007/10/03)
Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.