86187-88-4Relevant academic research and scientific papers
Preparation and Atropisomerism of 1-(2-Aryl)-piperidin-2-ones
Moehrle,Jeandree,Breitmaier,Rohonczy
, p. 473 - 485 (2007/10/03)
Course and rate of the dehydrogenation of N-tertiary piperidines dependent on their substitution in 4-position and on the hydroxy bearing neighbor group were examined, using mercury(II)-EDTA and the model amino alcohols 1a-1e, 3a-3f, 8a-8f and 10a-10f. The results showed that increasing size of 4-substituents and neighbor groups too decreased the rate of reaction. The products from the 2-substituted benzylic alcohols, the 2-piperidones 7a-7g, 9a-9g and 11a-11g demonstrated atropisomerism. In the case of chiral neighbor groups diastereomeric mixtures were formed.
(Benzoylphenyl)piperidines: A new class of immunomodulators
Bellamy,Chazan,Dodey,Dutartre,Ou,Pascal,Robin
, p. 1545 - 1552 (2007/10/02)
A series of (benzoylphenyl)piperidines has been synthesized and evaluated for activity as immunomodulators. Several of these compounds show good activity in primary screening on the basis of the lymphocytes mitogenic response to Con A, PHA, and PWM. A chloro group in position 4 of the benzoyl moiety as well as an amino group (or a carbamate derivative) para to the piperidine nucleus seems to be essential for activity. The depicted compounds may be considered as the first examples of a new series of immunomodulators.
