861887-46-9Relevant academic research and scientific papers
IMIDAZO-PYRAZOLES AS GPR119 INHIBITORS
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Page/Page column 52, (2011/06/19)
Compounds of formula (I) wherein: X is (A) or (B); Y is O or a bond; R1 is -C(O)-O-R3 or R2 is hydrogen, cyano, C1-C6 alkyl, or C3-C6 cycloalkyl; R5 is hydrogen, cyano
4-PHENOXYMETHYLPIPERIDINES AS MODULATORS OF GPR119 ACTIVITY
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Page/Page column 52-53, (2010/04/03)
The present invention provides compounds of Formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent; diseases or disorders associated with the activity of GPR119.
GPR 119 MODULATORS
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Page/Page column 71-72, (2010/11/18)
Compounds of Formula (I) that modulate the activity of the G -protein-coupled receptor GPFM 19 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein.
COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
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Page/Page column 42, (2009/10/18)
The invention provides compounds of Formula (I): pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
Modification of alkoxo ligands of BINOL-Ti ladder: Isolation and X-ray crystallographic analysis
Mikami, Koichi,Matsumoto, Yousuke,Xu, Ling
, p. 4159 - 4167 (2008/10/09)
The stable binaphthol-titanium ladder complexes have been successfully prepared by using bulky alkoxo ligands. From the secondary OR ligand (cyclohexyloxo, 2,4-dimethyl-3-pentyloxo or 2-adamantyloxo) and terially OR ligand (tert-butyloxo, 1-adamantyloxo), partial hydrolysis proceeded to give the μ3-oxo titanium complexes. The use of [Ti(BINOLato)(OEt)2]n made it possible to prepare the Ti(BINOLato)(OR)2 complexes using alcohols (ROH) of high boiling point (R = cyclohexyl, 2-adamantyl, 1-adamantyl). X-ray analyses of [(R)-1,1′-bi-2-naphtholato]bis(O-2,4-dimethyl-3-pentyloxo)titanium and [(R)-3,3′-dimethyl-1,1′-bi-2-naphtholato]bis(2-adamantyloxo)titanium showed a good agreement with the estimated ladder complexes. The catalytic activity of BINOL-Ti catalyst analogues, obtained by partial hydrolysis of Ti(BINOLato)(OR)2 with wet MS 4A was studied in asymmetric glyoxylate-ene reaction by two methods. Moderate to good chemical yields and enantioselectivities were obtained.
