861997-65-1

Upstream product

• 81028-03-7 (Z)-4-benzyloxy-but-2-en-1-ol 
• 305-53-3 monosodium iodoacetate 
• 79-08-3 bromoacetic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 861997-58-2 ((Z)-4-Benzyloxy-but-2-enyloxy)-acetic acid isopropyl ester 
• 878006-92-9 ((Z)-4-Benzyloxy-but-2-enyloxy)-acetic acid methyl ester 
• 777891-01-7 (Z)-4-Benzyloxy-2-((Z)-4-benzyloxy-but-2-enyloxy)-but-2-enoic acid isopropyl ester 
• 847228-87-9 (E)-4-Benzyloxy-2-((Z)-4-benzyloxy-but-2-enyloxy)-but-2-enoic acid isopropyl ester 
• 861997-59-3 4-Benzyloxy-2-((Z)-4-benzyloxy-but-2-enyloxy)-3-hydroxy-butyric acid isopropyl ester 

Relevant academic research and scientific papers

Total Synthesis and Structural Assignment of (?)-Fusaequisin A

(?)-Fusaequisin A is an irregularly assembled polyketide isolated from the ascomycete Fusarium equiseti. Fusaequisin A shares a carbon backbone with curvicollide C from the ascomycete Podospora curvicolla but its absolute configuration remained hitherto u

Catalytic asymmetric claisen rearrangement of gosteli-type allyl vinyl ethers: Total synthesis of (-)-9,10-dihydroecklonialactone B

The enantioselective synthesis of (-)-9,10-dihydroecklonialactone B is described. The catalytic asymmetric Claisen rearrangement of a Gosteli-type allyl vinyl ether was utilized to afford an acyclic α-keto ester building block endowed with functionality a

Enantioselective synthesis of the C8-C20 segment of curvicollide C

The enantioselective synthesis of the C8-C20 fragment of curvicollide C has been accomplished. A catalytic asymmetric Claisen rearrangement (CAC), a diastereoselective methyl cupration of an alkynoate, and a Julia-Kocienski olefination served as key C/C-connecting transformations.

Ester dienolate [2,3]-Wittig rearrangement in natural product synthesis: Diastereoselective total synthesis of the triester of viridiofungin A, A 2, and A4

An ester dienolate [2,3]-Wittig rearrangement was utilized to access the alkylated citric acid skeleton 6 that is characteristic for the viridiofungins and other members of the alkyl citrate family of secondary natural products. The [2,3]-sigmatropic rearrangement of (Z,Z)-15 provided the rearrangement product (±)-syn-16 in moderate yield and with very good diastereoselectivity. A Julia-Kocienski olefination efficiently served to connect the polar head (±)-syn-26 with the lipophilic tail (32a-c) of the viridiofungins. Amide formation between the racemic viridiofungin precursors 35a-c and the enantiomerically pure amino acid L-tyrosine methyl ester followed by preparative reversed-phase HPLC provided the isopropyl dimethyl ester of viridiofungin A ((+)-39a), A2 ((+)-39b), and A4 ((+)-39c) as well as the nonnatural diastereomers (-)-38a-c.