86207-76-3

Upstream product

• 108-30-5 succinic acid anhydride 
• 612-25-9 2-Nitrobenzyl alcohol 

Relevant academic research and scientific papers

Nitrobenzyl esters as potential conjugated alkylating and differentiation promoting agents: Antitumor effect in vivo

A series of ortho and para-nitrobenzyl esters of short chain fatty acids (C2 to C5) and of the lipophilic aminoacid, L-valine, and some other o-nitrobenzylated products were prepared. Bioreductive or hydrolytic cleavages of these compounds could release both differentiation promoting agents such as butyric acid and electrophilic moieties able to alkylate DNA. The antitumor effects of these compounds, either alone and/or associated with an immunostimulating agent (corynebacterium parvum, CP) or interferon (IFN) treatment, was studied using the 180 TG Crocker Sarcoma grafted onto Swiss mice. Based on the mean survival time and the final survival rate, the most active compounds used alone were the o-nitrobenzyl acetate and the 0-nitrobenzyl butyrate. Previous stimulation of the immune competent cells by CP before antitumor treatment increased the efficiency of most of the nitrobenzylated derivatives studied. The association with IFN did not significantly improve the antitumor effect.

Chitosan-based nanocarriers with ph and light dual response for anticancer drug delivery

Currently, the major challenge for cancer treatment is to develop new types of smart nanocarriers that can efficiently retain the encapsulated drug during blood circulation and quickly release the drug in tumor cells under stimulation. In this study, the

Photo-responsive shell cross-linked micelles based on carboxymethyl chitosan and their application in controlled release of pesticide

An amphiphilic carboxymethyl chitosan conjugate with photolabile 2-nitrobenzyl side groups (NBS-CMCS) was synthesized, which could self-assemble into polymeric micelles in aqueous condition following by adding dropwise dialdehyde to form a cross-linking s

Near-infrared light and pH dual-response oleic acid derivative nano drug-loaded material as well as preparation method and application thereof

The invention belongs to the field of medicines, and discloses a near-infrared light and pH dual-response oleic acid derivative nano drug-loaded material as well as a preparation method thereof. The nano carrier material is formed by grafting oleic acid o

Near-infrared light response photodynamic drug controlled release system and preparation method thereof

The invention relates to a near-infrared light response photodynamic drug controlled release system and a preparation method thereof. The near-infrared light response photodynamic drug controlled release system and the preparation method thereof can effec

A Versatile Approach for Site-Specific Lysine Acylation in Proteins

Using amber suppression in coordination with a mutant pyrrolysyl-tRNA synthetase-tRNAPylpair, azidonorleucine is genetically encoded in E. coli. Its genetic incorporation followed by traceless Staudinger ligation with a phosphinothioester allows the convenient synthesis of a protein with a site-specifically installed lysine acylation. By simply changing the phosphinothioester identity, any lysine acylation type could be introduced. Using this approach, we demonstrated that both lysine acetylation and lysine succinylation can be installed selectively in ubiquitin and synthesized histone H3 with succinylation at its K4 position (H3K4su). Using an H3K4su-H4 tetramer as a substrate, we further confirmed that Sirt5 is an active histone desuccinylase. Lysine succinylation is a recently identified post-translational modification. The reported technique makes it possible to explicate regulatory functions of this modification in proteins.

Photo-responsive controlled-release nano-pesticide preparation and preparation method and application thereof

The invention relates to photo-responsive controlled-release nano-pesticide preparation and a preparation method and application thereof. A controlled-release effective constituent of the preparation is amphiphilic carboxymethyl chitosan derivative which

Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

Monoester of succinic acid (1-29), synthesised and characterised at our laboratory, were investigated with reference to their antifungal and antibacterial activities. The results concluded that though almost all the compounds were bioactive but the degree

An efficient method for the preparation of benzyl γ-ketohexanoates

Twenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia-XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethyl

Antibacterial β-lactam compounds

Novel β-lactam compounds classified into penem compounds, a process for preparing the same and use of such β-lactam compounds are disclosed. These β-lactam compounds exhibit excellent antimicrobial activities useful as pharmaceuticals or they are important intermediates for the synthesis of compounds having antimicrobial activities.