862201-39-6

Basic information

• Product Name: 2-(P-FLUOROPHENYL)-4-PHENYLPYRROLE
• Synonyms: 2-(P-FLUOROPHENYL)-4-PHENYLPYRROLE
• CAS NO: 862201-39-6
• Molecular Formula: C₁₆H₁₂FN
• Molecular Weight: 237.27
• Mol File: 862201-39-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(P-FLUOROPHENYL)-4-PHENYLPYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(P-FLUOROPHENYL)-4-PHENYLPYRROLE(862201-39-6)
• EPA Substance Registry System: 2-(P-FLUOROPHENYL)-4-PHENYLPYRROLE(862201-39-6)

Safety Data

• Hazardous Substances Data: 862201-39-6(Hazardous Substances Data)

Usage

Chemical structure

2-(P-FLUOROPHENYL)-4-PHENYLPYRROLE consists of a pyrrole ring (a five-membered aromatic heterocycle) with a p-fluorophenyl group at the 2-position and a phenyl group at the 4-position.

Class of compound

It belongs to the pyrrole class of organic compounds, which are five-membered aromatic heterocycles.

Substituents

The compound has a p-fluorophenyl group (a fluorinated aromatic hydrocarbon) at the 2-position and a phenyl group (a common aromatic hydrocarbon) at the 4-position.

Aromaticity

The presence of the pyrrole ring and the aromatic hydrocarbon substituents contribute to the compound's aromatic properties.

Potential applications

2-(P-FLUOROPHENYL)-4-PHENYLPYRROLE has potential applications in the field of organic chemistry, particularly as a building block for the synthesis of more complex molecules.

Research and development interest

Its properties and potential uses make it a subject of interest in the research and development of new materials and pharmaceuticals.

Upstream product

• 39833-45-9 3-(4-fluorophenyl)-1-phenylprop-2-yn-1-one 
• 1374152-38-1 1-(1-azidovinyl)-4-fluorobenzene 
• 122-78-1 phenylacetaldehyde 
• 100-52-7 benzaldehyde 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 22966-25-2 (E)-1-(4-fluorophenyl)-3-phenyl-2-propen-1-one 
• 862201-30-7 1-(4-fluorophenyl)-4-nitro-3-phenyl-butan-1-one 

Downstream Products

• 862201-41-0 5-(4-fluorophenyl)-2-nitroso-3-phenyl-1H-pyrrole 

Relevant articles and documents

Base-promoted ring-closing carbonyl-allene metathesis for the synthesis of 2,4-disubstituted pyrroles

A base-promoted ring-closing carbonyl-allene metathesis reaction of N-allenyl β-enaminones (generated in situ from N-propargyl β-enaminones) gives 2,4-disubstituted pyrroles with cleavage of the C(sp)-C(sp3) bond. This transition metal-free procedure generates 1 equiv. of acetic acid as the sole byproduct. A preliminary mechanistic study supports a stepwise [2 + 2] cycloaddition/retro [2 + 2] reaction pathway.

Reaction between 4-Nitro-1,3-diarylbutan-1-ones and Ammonium Acetate in the Presence of Morpholine and Sulfur: An Efficient Synthesis of 2,4-Diarylpyrroles

An efficient synthesis of 2,4-diarylpyrroles is described. Heating a mixture of a 4-nitro-1,3-diarylbutan-1-one and ammonium acetate in the presence of morpholine and sulfur afforded the corresponding 2,4-diarylpyrroles in excellent yields.

A modular synthesis of unsymmetrical tetraarylazadipyrromethenes

A stepwise route to unsymmetrical tetraarylazadipyrromethenes by a condensation of 2,4-diaryl-5-nitroso-pyrroles with 2,4-diarylpyrroles is described. This modular building-block approach allows for the introduction of up to four different aryl substituents on the azadipyrromethene and is tolerant of a varied substituent set. An efficient synthesis of the 2,4-diarylpyrroles building blocks from 1,3-diaryl-4-nitro-butan-1-ones by nitro hydrolysis to a keto-aldehyde and subsequent ammonia condensation reaction has been achieved. The facile conversion of 2,4-diarylpyrroles into their α-nitroso analogues by their reaction with sodium nitrite generated the second building block required for the synthesis.