86232-54-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-6Methyl-2-Methoxy Phenol is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Bromo-6Methyl-2-Methoxy Phenol is used as a building block in the production of agrochemicals, leveraging its antimicrobial and antifungal properties to enhance crop protection and yield.
Used in Fragrance and Flavoring Industry:
4-Bromo-6Methyl-2-Methoxy Phenol is utilized as a key component in the creation of fragrances and flavorings, contributing to the unique scents and tastes in various consumer products.
Used in Fine Chemicals Production:
This chemical compound serves as a building block in the production of fine chemicals, where its specific properties can be harnessed to create high-quality specialty chemicals for diverse applications.
Used as a Reagent in Chemical Research:
4-Bromo-6Methyl-2-Methoxy Phenol is employed as a reagent in chemical research and laboratory experiments, facilitating the exploration of new chemical reactions and the development of innovative chemical processes.

Upstream product

• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 
• 2896-67-5 2-methyl-6-methoxyphenol 
• 128-08-5 N-Bromosuccinimide 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 

Downstream Products

• 71295-21-1 5-bromo-2,3-dimethoxybenzaldehyde 
• 302321-77-3 4-bromo-6,6-dimethoxy-2-methyl-2,4-cyclohexadien-1-one 
• 910575-54-1 2-benzyloxy-5-bromo-1-methoxy-3-methyl-benzene 
• 173900-47-5 4-hydroxy-3-methoxy-5-methylbenzonitrile 
• 486413-43-8 2-methoxy-6-methyl-4-trimethylsilanyl-phenol 

Relevant academic research and scientific papers

SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF

The present disclosure relates to substituted hydroxystilbene compounds and derivatives, specifically 2-substituted hydroxystilbene compounds and derivatives, the synthesis of such compounds and their use in therapy.

The discovery of a novel route to highly substituted -tropolones enables expedient entry to the core of the gukulenins

A simple and general method for the synthesis of highly substituted α-tropolone ethers that allows rapid access to the bis(tropolone) core of the antiproliferative metabolites (-)-gukulenins A and F (3, 4) is described. The reaction proceeds by thermolyti

Selected Cgrp-Antagonists, Processes for Preparing Them and Their Use as Pharmaceutical Compositions

The invention relates to CGRP-antagonists of general formula (I), wherein R1, R2, R3, R4 and R5 are defined in claim 1, to the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures salts and salt hydrates thereof, in particular to 10 salts thereof, which are physiologically compatible with acids or inorganic or organic bases and to compounds of general formula (I), wherein one or several hydrogen atoms are substituted by deuterium. Drugs containing said compounds, the use thereof and a method for the production thereof are also disclosed.

Selected CGRP antagonists, process for their preparation as well as their use as medicaments

Heterocyclic esters (I), their tautomers, diastereomers, enantiomers, hydrates, mixtures and (hydrated) salts, particularly physiologically acceptable salts with (in)organic acids and bases, that are antagonists of calcitonin gene-related peptide (CGRP) a

Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions

The present invention relates to the CGRP-antagonists of general formula I wherein R1, R2, R3 and R4 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I wherein one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

CGRP ANTAGONISTS, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS MEDICAMENTS

The invention relates to CGRP antagonists of general formula (I) in which: R1, R2, R3, R4 and X are defined as in Claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts as well as the hydrates of the salts, in particular, their physiologically compatible salts with inorganic or organic acids and bases, and those compounds of general formula (I) in which one or more hydrogen atoms are replaced by deuterium. The invention also relates to medicaments containing these compounds, the use thereof, and to methods for producing them.

Intermolecular Diels-Alder reactions of brominated masked o-benzoquinones with electron-deficient dienophiles. A detour method to synthesize bicyclo[2.2.2]octenones from 2-methoxyphenols

Intermolecular Diels-Alder reactions of masked o-benzoquinones, i.e., 6,6-dimethoxy-2,4-cyclohexadienones 5-7 and 21-24 generated from 2-methoxyphenols 1-3 and 17-20, respectively, with electron-deficient dienophiles leading to highly functionalized bicyclo[2.2.2]octenones are described. The masked o-benzoquinones (MOBs) 5-7 underwent Diels-Alder cycloadditions with methyl acrylate, methyl methacrylate, and methyl vinyl ketone to provide bicyclo[2.2.2]octenones 13a-c to 15a-c (direct method) in low to moderate yields with the concomitant formation of considerable amounts of dimers 9-11. To retard dimerization and to improve the yields of the requisite bicyclo[2.2.2]octenones, a detour method comprised of sequential bromination of 2-methoxyphenols 1-4, oxidation and Diels-Alder reaction, and debromination has been developed. The oxidation of bromophenols 17-20 produced MOBs 21-24 which are stable enough to be isolated. The MOBs 21-24 underwent cycloaddition with electron-deficient dienophiles in a very efficient manner to afford the corresponding cycloadducts 25a-c to 28a-c in good to high yields without self-dimerization. When the cycloadducts 25a-c to 28a-c were treated with either Bu3SnH/AIBN or tributylammonium formate-palladium reagent, the corresponding debrominated products 13a-c to 16a-c were obtained in high to excellent yields. In general, the cycloadducts 13a-c to 15a-c were obtained in 20-40% higher yields via the detour method than those via the direct method. In both routes, the Diels-Alder reactions proceeded in a highly regio- and stereoselective manner to furnish a single cycloadduct in each case.

Synthesis of stable bromo-substituted masked o-benzoquinones and their application to the synthesis of bicyclo[2.2.2]octenones

Preparation of stable equivalents of some unstable masked o-benzoquinones and their use in the preparation of bicyclo[2.2.2]octenones is described.

SYNTHESIS OF 5-HALOGEN-SUBSTITUTED 2,3-DIHYDROXYPHENYLACETIC ACIDS, THEIR ESTERS, AND 2,3-DIMETHOXYPHENYLACETOHYDROXAMIC ACIDS

Many-stage general methods were developed for the synthesis of 5-bromo- or 5-chloro-substituted 2,3-dimethoxyphenylacetic acids from o-vanilin.Methods were also developed for their conversion into the corresponding hydroxamic acids, 2,3-dihydroxyphenylace