86239-16-9Relevant academic research and scientific papers
Method and catalyst system for preparation of aromatic malononitrile
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Paragraph 0054, (2020/04/17)
The invention provides a method and a catalyst system for preparation of aromatic malononitrile. The preparation method of the aromatic malononitrile comprises the step of reacting at least one aromatic iodine compound with malononitrile in a solvent in t
Preparation of O-Protected Cyanohydrins by Aerobic Oxidation of α-Substituted Malononitriles in the Presence of Diarylphosphine Oxides
Zhang, Dapeng,Lian, Mingming,Liu, Jia,Tang, Shukun,Liu, Guangzhi,Ma, Cunfei,Meng, Qingwei,Peng, Haisheng,Zhu, Daling
, p. 2597 - 2601 (2019/04/17)
A mild, reagent-cyanide-free, and efficient synthesis of O-phosphinoyl-protected cyanohydrins from readily available α-substituted malononitriles was realized using diarylphosphine oxides in the presence of O2. Mechanistic studies indicated that in addition to the initial aerobic oxidation of the malononitrile derivative notable features of this process include the formation of a tetrahedral intermediate and a subsequent intramolecular rearrangement. The phosphinoyl-protecting group can be removed by alcoholysis or by reduction with DIBAL-H.
Synthesis of substituted isoquinolines via Pd-catalyzed cross-coupling approaches
Todorovic, Nick,Awuah, Emelia,Albu, Silvia,Ozimok, Cory,Capretta, Alfredo
supporting information; experimental part, p. 6180 - 6183 (2012/01/03)
Palladium complexes incorporating ligands based on a 1,3,5,7-tetramethyl-2, 4,8-trioxa-6-phosphaadamantanyl scaffold were used to catalyze the arylation of ethyl cyanoacetate, malononitrile, and various ketones. The products from these reactions can be el
A highly efficient catalytic system for cross-coupling of aryl chlorides and bromides with malononitrile anion by palladium carbene complexes
Gao, Chengwei,Tao, Xiaochun,Qian, Yanlong,Huang, Jiling
, p. 1444 - 1445 (2007/10/03)
Six imidazolium chlorides (1-6) as precursors of 1,3-diaryl substituted N-heterocyclic carbene ligands were synthesized and evaluated in palladium-catalyzed cross-coupling reactions of aryl chlorides and bromides with malononitrile in the presence of NaH.
Palladium-catalysed 1,4-Arylation/Alkylation of Buta-1,3-diene with Halogenoarenes and Stabilised Anions
Uno, Mitsunari,Takahashi, Terumasa,Takahashi, Shigetoshi
, p. 647 - 651 (2007/10/02)
In the presence of a palladium-phosphine catalyst, buta-1,3-diene reacts with halogenoarenes and -CH(CN)2 to give 1,4-arylation/alkylation products of the diene, ArCH2CH=CHCH2C(Ar)(CN)2 (6), in moderate yields.In this reaction, two carbon-carbo
A NEW APPROACH TO ARYLMALONONITRILES
Yamaguchi, Shunro,Araki, Hisashi,Hanafusa, Terukiyo
, p. 685 - 688 (2007/10/02)
Arylmalononitriles were prepared from the corresponding benzoyl chlorides by three reaction steps.Treatment of the starting substances with cyanotrimethylsilane in the presence of pyridine gave dicyanotrimethylsiloxymethylbenzenes, which were transformed
A New Method of Synthesis of Arylmalononitriles catalysed by a Palladium Complex
Uno, Mitsunari,Seto, Koji,Takahashi, Shigetoshi
, p. 932 - 933 (2007/10/02)
Arylmalononitriles are prepared in good yields using a palladium-catalysed coupling reaction between aryl halides and malononitrile.
