86242-81-1Relevant articles and documents
Reaction of (Vinyloxyalkyl)amines with Chloral Hydrate
Kukharev, B. F.,Stankevich, V. K.,Klimenko, G. R.
, p. 591 - 596 (2007/10/03)
Reaction of (2-vinyloxyethyl)amine with chloral hydrate produces unstable 2,2,2-trichloro-1-ethanol, which is cleaved to give N-(2-vinyloxyethyl)formamide.The latter undergoes cyclization into thermodynamically more stable 3-formyl-2-methyl-1,3-oxazolidine during isolation.Similar cyclic and linear formamides were obtained from chlral hydrate and other vinyl-substituted 1,2-, 1,3-, and 1,4-aminoalcohols.N-(Hydroxyalkyl)-formamides were isolated as by-products.