86264-61-1 Usage
Uses
Used in Pharmaceutical Industry:
(R)-N-(2-Acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl)acetamide is used as a potential pharmaceutical agent for its possible biological activity, which may contribute to the development of new drugs. Its unique structure allows for the exploration of its interactions with biological systems and its potential therapeutic effects.
Used in Drug Development:
In the field of drug development, (R)-N-(2-Acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl)acetamide serves as a building block for the synthesis of new compounds with potential medicinal properties. Its versatile chemical structure can be modified to create derivatives that may exhibit enhanced or novel pharmacological effects.
Used in Materials Science:
(R)-N-(2-Acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl)acetamide is used in materials science for its potential to contribute to the development of new materials with unique properties. Its reactivity and structural characteristics may lead to the creation of innovative materials with applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 86264-61-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,2,6 and 4 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 86264-61:
(7*8)+(6*6)+(5*2)+(4*6)+(3*4)+(2*6)+(1*1)=151
151 % 10 = 1
So 86264-61-1 is a valid CAS Registry Number.
86264-61-1Relevant academic research and scientific papers
Stereospecific Total Synthesis of 9-Aminoanthracyclines: (+)-9-Amino-9-deoxydaunomycin and Related Compounds
Ishizumi, Kikuo,Ohashi, Naohito,Tanno, Norihiko
, p. 4477 - 4485 (2007/10/02)
9-amino-9-deoxydaunomycin and related compounds, in which the hydroxyl group at the 9-position of daunomycin is replaced by an amino group, have been synthesized.Asymmetry was introduced into the synthetic sequence for the AB synthon by resolution of the intermediate amino ester or acetamido acid to afford (R)-(-)-2-acetyl-2-acetamido-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene, which was converted to the tetracyclic amido ketones by Friedel-Crafts acylation with phthalic anhydride or its 3-methoxy derivative.The resulting regioisomers 4- and 1-methoxy compounds were separed, after methylation and selective demethylation, by crystallization and preparative TLC.The required introduction of the C7-hydroxyl function proceeded stereosepcifically via a three-step reaction sequence involving formation of an oxazine compound.The silver trifluoromethane assisted glycosidation of the resulting aglycons with 2-deoxy-3,4-di-O-acetyl-D-erythro-pentopyranosyl bromide or N,O-bis(trifluoroacetyl)daunosaminyl chloride, followed by alkaline hydrolysis afforded the target glycosides.The work reported herein comprises an efficient, practical synthesis of 9-amino-9-deoxydaunomycin and its analogues with the same stereochemistry as in the naturally occurring anthracyclines.
