86264-76-8 Usage
Uses
Given the provided materials, specific uses for Acetamide, N-[1,2,3,4,6,11-hexahydro-5,12-dihydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-6,11-dioxo-2-naphthacenyl]-,(R)are not explicitly mentioned. However, based on the compound's characteristics and potential applications, it can be inferred that it may be used in the following ways:
Used in Pharmaceutical Development:
Acetamide, N-[1,2,3,4,6,11-hexahydro-5,12-dihydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-6,11-dioxo-2-naphthacenyl]-,(R)may be utilized as an active pharmaceutical ingredient or a key intermediate in the synthesis of drugs due to its complex structure and functional groups.
Used in Chemical Synthesis:
Acetamide,N-[1,2,3,4,6,11-hexahydro-5,12-dihydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-6,11-dioxo-2-naphthacenyl]-,(R)-'s unique molecular structure and functional groups could make it a valuable building block or reagent in the synthesis of other complex organic molecules, potentially for use in various chemical industries.
Used in Research and Development:
Due to its chiral center and diverse functional groups, Acetamide, N-[1,2,3,4,6,11-hexahydro-5,12-dihydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-6,11-dioxo-2-naphthacenyl]-,(R)could be employed in research settings to study the effects of stereochemistry on molecular properties and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 86264-76-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,2,6 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 86264-76:
(7*8)+(6*6)+(5*2)+(4*6)+(3*4)+(2*7)+(1*6)=158
158 % 10 = 8
So 86264-76-8 is a valid CAS Registry Number.
86264-76-8Relevant academic research and scientific papers
Stereospecific Total Synthesis of 9-Aminoanthracyclines: (+)-9-Amino-9-deoxydaunomycin and Related Compounds
Ishizumi, Kikuo,Ohashi, Naohito,Tanno, Norihiko
, p. 4477 - 4485 (2007/10/02)
9-amino-9-deoxydaunomycin and related compounds, in which the hydroxyl group at the 9-position of daunomycin is replaced by an amino group, have been synthesized.Asymmetry was introduced into the synthetic sequence for the AB synthon by resolution of the intermediate amino ester or acetamido acid to afford (R)-(-)-2-acetyl-2-acetamido-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene, which was converted to the tetracyclic amido ketones by Friedel-Crafts acylation with phthalic anhydride or its 3-methoxy derivative.The resulting regioisomers 4- and 1-methoxy compounds were separed, after methylation and selective demethylation, by crystallization and preparative TLC.The required introduction of the C7-hydroxyl function proceeded stereosepcifically via a three-step reaction sequence involving formation of an oxazine compound.The silver trifluoromethane assisted glycosidation of the resulting aglycons with 2-deoxy-3,4-di-O-acetyl-D-erythro-pentopyranosyl bromide or N,O-bis(trifluoroacetyl)daunosaminyl chloride, followed by alkaline hydrolysis afforded the target glycosides.The work reported herein comprises an efficient, practical synthesis of 9-amino-9-deoxydaunomycin and its analogues with the same stereochemistry as in the naturally occurring anthracyclines.
