862735-86-2

Upstream product

• 862735-96-4 (2R,3R)-3-(dimethyl-phenyl-silanyl)-oxirane-2-carboxylic acid 
• 67-56-1 methanol 
• 101844-21-7 (E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-ol 
• 862735-85-1 [(2R,3R)-3-(dimethyl-phenyl-silanyl)-oxiran-2-yl]methanol 
• 766-77-8 Dimethylphenylsilane 

Downstream Products

• 862735-87-3 (2R,3R)-3-(dimethyl-phenyl-silanyl)-2-hydroxy-hex-4-ynoic acid methyl ester 
• 862735-77-1 (Z)-(2R,3R)-3-(dimethyl-phenyl-silanyl)-2-trimethylsilanyloxy-hex-4-enoic acid methyl ester 
• 862735-97-5 (Z)-(2R,3R)-3-(dimethyl-phenyl-silanyl)-2-hydroxy-hex-4-enoic acid methyl ester 

Relevant academic research and scientific papers

A convenient multigram synthesis of highly enantioenriched methyl 3-silylglycidates

A multigram scale synthesis of the four stereoisomers of methyl 3-silylglycidates (epoxysilanes) with high enantiopurity is described. Key reactions include a Sharpless asymmetric epoxidation (SAE) of a trans-vinylsilane and an enzymatic resolution of a r

Synthesis and [4 + 2]-annulation of enantioenriched (Z)-crotylsilanes: Preparation of the C1-C13 fragment of bistramide A

(Chemical Equation Presented) New chiral crotylsilanes that bear a (Z)-olefin geometry were synthesized in high enantiopurity. The reagents participate in [4 + 2]-annulations with aldehydes to give stereochemically complementary pyrans (relative to (E)-crotylsilanes) bearing 2,6-cis-5,6-cis and 2,6-trans-5,6-cis relationships of peripheral functionalities. A stereoselective synthesis of the C1-C13 fragment of bistramide A is also described highlighting this annulation strategy.