862791-08-0

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 665-27-0 1,5-quinide 
• 185810-83-7 (1S,3R,4R,5R)-3-benzyloxy-1,4-dihydroxycyclohexane-1,5-carbolactone 

Downstream Products

• 1233376-59-4 (4R,6R,7R)-1-(2-(2-bromophenyl)ethyl)-4,7-di(tert-butyldimethylsilyloxy)-4,5,6,7-tetrahydro-1H-indole-4,6-carbolactone 
• 1233376-56-1 (4R,6R,7S)-2-benzyl-4,7-di(tert-butyldimethylsilyloxy)-4,5,6,7-tetrahydrobenzo[b]thiophene-4,6-carbolactone 
• 1233376-46-9 (4R,6R,7S)-4,7-di(tert-butyldimethylsilyloxy)-2-(1-phenylvinyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-4,6-carbolactone 
• 1233335-43-7 (4R,6R,7S)-4,7-dihydroxy-2-phenyl-4,5,6,7-tetrahydrobenzo[b]thiophene-4,6-carbolactone 
• 1233335-41-5 (4R, 6R, 7S)-4,7-di(tert-butyldimethylsilyloxy)-2-phenyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4,6-carbolactone 
• 1198790-99-6 sodium (1R,4S,5R)-1,4,5-trihydroxy-3-(benzo[b]thiophen-2-yl)methoxycyclohexan-1-carboxylate 
• 1206715-92-5 (2R)-2-propyl-3-dehydroquinic acid 
• 1206715-82-3 (2R)-2-allyl-3-dehydroquinic acid 
• 862791-37-5 (1R,3R,4R)-1,4-bis(tert-butyldimethylsilyloxy)-5-[4-(trifluoromethyl)phenyl]cyclohex-5-ene-1,3-carbolactone 
• 862791-41-1 (1R,3R,4R)-1,4-bis(tert-butyldimethylsilyloxy)-5-[3-(trifluoromethyl)phenyl]cyclohex-5-ene-1,3-carbolactone 
• 862791-53-5 (1R,3R,4R)-1,4-bis(tert-butyldimethylsilyloxy)-5-(3,5-difluorophenyl)cyclohex-5-ene-1,3-carbolactone 
• 862791-50-2 3-[(1R,4R,5R)-1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-7-oxo-6-oxa-bicyclo[3.2.1]oct-2-en-3-yl]-benzoic acid methyl ester 
• 862791-47-7 (1R,3R,4R)-1,4-bis(tert-butyldimethylsilyloxy)-5-(3-nitrophenyl)cyclohex-5-ene-1,3-carbolactone 
• 862791-44-4 (1R,3R,4R)-1,4-bis(tert-butyldimethylsilyloxy)-5-(3-hydroxyphenyl)cyclohex-5-ene-1,3-carbolactone 

Relevant academic research and scientific papers

Structure-based design, synthesis, and biological evaluation of inhibitors of Mycobacterium tuberculosis type II dehydroquinase

The syntheses by Suzuki cross-coupling of 12 5-aryl analogues of the known inhibitor (LR,3/2,4R)-1,3,4-trihydroxycyclohex-5-en-1-carboxylic acid are reported. These compounds were found to be reversible competitive inhibitors against Mycobacterium tubercu

COMPETITIVE INHIBITORS OF TYPE II DEHYDROQUINASE ENZYME

The present invention is directed to a compound of formula (I), its diastereoisomers, its enantiomers or its pharmaceutically acceptable salts or solvates, formula (I), to procedures of obtaining the same, to intermediates thereof, and use as competitive inhibitors of the third enzyme of the shikimic acid pathway, the type II dehydroquinase.

Competitive inhibitors of type ii dehydroquinase enzyme

The present invention is directed to a compound of formula I, its diastcrcoisomcrs, its enantiomers or its pharmaceutically acceptable salts or solvates, to procedures of obtaining the same, to intermediates thereof, and use as competitive inhibitors of