862876-03-7

Basic information

• Product Name: N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide
• Synonyms: N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide
• CAS NO: 862876-03-7
• Molecular Weight: 269.343
• Mol File: 862876-03-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide(862876-03-7)
• EPA Substance Registry System: N-(4-methoxyphenyl)-2-methyl-2-phenylpropanamide(862876-03-7)

Safety Data

• Hazardous Substances Data: 862876-03-7(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 7471-26-3 N-(4-methoxyphenyl)benzenesulphonamide 
• 36293-05-7 2-methyl-2-phenylpropanoyl chloride 
• 98-86-2 acetophenone 
• 201230-82-2 carbon monoxide 
• 20265-97-8 p-anisidine hydrochloride 
• 98-83-9 isopropenylbenzene 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 89372-28-1 1-(2-methyl-2-phenylpropanoyl)-1H-imidazole 

Relevant articles and documents

Palladium-Catalyzed Markovnikov Hydroaminocarbonylation of 1,1-Disubstituted and 1,1,2-Trisubstituted Alkenes for Formation of Amides with Quaternary Carbon

Hydroaminocarbonylation of alkenes is one of the most promising yet challenging methods for the synthesis of amides. Herein, we reported the development of a novel and effective Pd-catalyzed Markovnikov hydroaminocarbonylation of 1,1-disubstituted or 1,1,2-trisubstituted alkenes with aniline hydrochloride salts to afford amides bearing an α quaternary carbon. The reaction makes use of readily available starting materials, tolerates a wide range of functional groups, and provides a facile and straightforward approach to a diverse array of amides bearing an α quaternary carbon. Mechanistic investigations suggested that the reaction proceeded through a palladium hydride pathway. The hydropalladation and CO insertion are reversible, and the aminolysis is probably the rate-limiting step.

Amide Boc de-protection method

The invention discloses an amide Boc de-protection method. The amide Boc de-protection method includes carrying out reaction on Boc protected amide III and amine IV under the condition of the presenceof palladium catalysts to generate new amide V. 8-aminoquinoline can be used as a guide group to be applied to chemical reaction, a process for synthesizing the new amide by means of de-protection isprovided, protecting groups can be easily removed by means of palladium catalysis, the new amide can be generated, and the reaction is high in efficiency. The amide Boc de-protection method has the advantages of environmental friendliness, recyclability and the like.

Unique physicochemical and catalytic properties dictated by the B3NO2 ring system

The expansion of molecular diversity beyond what nature can produce is a fundamental objective in chemical sciences. Despite the rich chemistry of boron-containing heterocycles, the 1,3-dioxa-5-aza-2,4,6-triborinane (DATB) ring system, which is characterized by a six-membered B3NO2 core, remains elusive. Here, we report the synthesis of m-terphenyl-templated DATB derivatives, displaying high stability and peculiar Lewis acidity arising from the three suitably arranged boron atoms. We identify a particular utility for DATB in the dehydrative amidation of carboxylic acids and amines, a reaction of high academic and industrial importance. The three boron sites are proposed to engage in substrate assembly, lowering the entropic cost of the transition state, in contrast with the operative mechanism of previously reported catalysts and amide coupling reagents. The distinct mechanistic pathway dictated by the DATB core will advance not only such amidations, but also other reactions driven by multisite activation.