89372-28-1Relevant academic research and scientific papers
A comparison of catalysts to promote imidazolide couplings including the identification of 2-hydroxy-5-nitropyridine as a new, safe, and effective catalyst
Dunn, Peter J.,Hoffmann, Wilfried,Kang, Ying,Mitchell, John C.,Snowden, Martin J.
, p. 956 - 961 (2005)
Five catalysts were compared with respect to their safety and catalytic effectiveness for promoting imidazolide couplings. Reaction rate enhancement, shock sensitivity, and differential scanning calorimetry (DSC) data were considered in this analysis. 6-Chloro-1-hydroxybenzotriazole, which has been described in the literature as a safe catalyst, was found to be shock sensitive. 2-Hydroxy-5-nitropyridine is a new catalyst for this type of reaction and was found to be safe, effective, readily available, and similar in price to that of the 1-hydroxybenzotriazole, a common catalyst for promoting acylation reactions.
DBU catalysis of N,N'-carbonyldiimidazole-mediated amidations
Larrlvee-Aboussafy, Claude,Jones, Brian P.,Price, Kristin E.,Hardink, Mark A.,McLaughlin, Robert W.,Lillie, Brett M.,Hawkins, Joel M.,Vaidyanathan, Rajappa
supporting information; experimental part, p. 324 - 327 (2010/03/24)
(Figure presented) 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) has been found to catalyze the amidatlon of acyl imidazoles. The rate acceleration is especially evident with traditionally unreactlve, electron-deficient anilines. DBU is readily available and o
