863029-13-4Relevant academic research and scientific papers
The synthesis and structure-activity relationships of 3-amino-4- benzylquinolin-2-ones: Discovery of novel KCNQ2 channel openers
Hewawasam, Piyasena,Chen, Nathan,Ding, Min,Natale, Joanne T.,Boissard, Christopher G.,Yeola, Sarita,Gribkoff, Valentin K.,Starrett, John,Dworetzky, Steven I.
, p. 1615 - 1618 (2007/10/03)
3-Amino-4-benzylquinolin-2-ones have been identified as a novel class of KCNQ2 channel openers. Synthesis and SAR is described along with their electrophysiological evaluation as activators of the cloned mKCNQ2 channel expressed in Xenopus laevis oocytes.
