19073-14-4

Basic information

• Product Name: 4-(1,3-Dioxolan-2-yl)aniline
• Synonyms: 4-(1,3-dioxolan-2-yl)aniline;4-(1,3-Dioxolan-2-yl)phenylamine;4-Aminobenzaldehyde ethylene acetal;4-(1,3-Dioxolan-2-yl)
• CAS NO: 19073-14-4
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 19073-14-4.mol
• Article Data: 28

Chemical Properties

• Melting Point: 75-79 °C
• Boiling Point: 313.119°C at 760 mmHg
• Flash Point: 156.348°C
• Appearance: /
• Density: 1.203g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.44±0.10(Predicted)
• CAS DataBase Reference: 4-(1,3-Dioxolan-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,3-Dioxolan-2-yl)aniline(19073-14-4)
• EPA Substance Registry System: 4-(1,3-Dioxolan-2-yl)aniline(19073-14-4)

Safety Data

• Hazardous Substances Data: 19073-14-4(Hazardous Substances Data)

Usage

Uses

4-?(1,?3-?Dioxolan-?2-?yl)?aniline is a reagent used in the preparation of luminogens and fluorescent polyimides. Also used in the preparation of a novel class of small molecule caspase-3 inihibitors.

InChI:InChI=1/C9H11NO2/c10-8-3-1-7(2-4-8)9-11-5-6-12-9/h1-4,9H,5-6,10H2

Upstream product

• 2403-53-4 2-(4-nitrophenyl)-1,3-dioxolane 
• 555-16-8 4-nitrobenzaldehdye 
• 107-21-1 ethylene glycol 
• 52161-21-4 N-[4-(1,3-dioxolan-2-yl)phenyl]acetamide 

Downstream Products

• 863029-84-9 N-[4-(1-hydroxyallyl)phenyl]methanesulfonamide 
• 100632-81-3 ibutilide 
• 83922-54-7 N-(4-formylphenyl)methanesulfonamide 
• 650628-82-3 3-chloro-N-[4-(1,3-dioxolan-2-yl)phenyl]propanamide 
• 650628-80-1 N-[4-(1,3-dioxolan-2-yl)phenyl]-2-methoxyacetamide 
• 650628-84-5 N-(4-formylphenyl)-2-(2-methoxyethoxy)acetamide 
• 120219-05-8 N-[4-(hydroxyiminomethyl)phenyl]-N'-n-propoxycarbonylmethylurea 
• 1004324-97-3 N-(4-(1,3-dioxolan-2-yl)phenyl)-2,4-dinitrobenzenesulfonamide 
• 1224886-44-5 C₁₇H₁₇NO₄ 
• 1508310-55-1 2-[4-(ethylsulfonyl)phenyl]-N-(4-formylphenyl)acetamide 
• 1508310-35-7 2-[4-(ethylsulfonyl)phenyl]-N-(4-{[[(4-methylphenyl)methyl](propyl)amino]methyl}phenyl)acetamide 
• 1508310-36-8 N-(4-{[[(4-ethylphenyl)methyl](propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide 
• 1508310-37-9 N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide 
• 1508310-56-2 2-[4-(ethylsulfonyl)phenyl]-N-{4-[(propylamino)methyl]phenyl}acetamide 

Relevant articles and documents

An efficient, simple synthesis of 4-azidobenzaldehyde

A three-pot synthesis of 4-azidobenzaldehyde from 4-nitrobenzaldehyde in overall yield of 71% is described. The new synthesis is superior in its ease of reproducibility and reduction of waste side products.

Discovery of tert-amine-based RORγt agonists

The nuclear receptor retinoic acid receptor-related orphan receptor gamma-t (RORγt) is a transcription factor regulating Th17 cell differentiation and proliferation from naive CD4+ T cells. Since Th17 cells have demonstrated the antitumor efficacy by eliciting remarkable activation of CD8+ T cells, RORγt agonists could be applied as potential small molecule therapeutics for cancer immunotherapy. Based on the previously reported RORγt agonist 1 and its resolved co-crystal structure, a series of new tertiary amines were designed, synthesized and biologically evaluated, yielding optimal moieties with improved chemical properties and biological responses. The combination of these optimal moieties resulted in identification of novel RORγt agonists such as 8b with further elevated RORγt agonism responses at a target-based level as well as in cell-based assays, which provided some structural knowledge for further optimization of RORγt agonists as small molecule therapeutics for cancer immunotherapy.

Carboxylic acid ester derivative and medical uses thereof

The invention relates to a compound represented by a general formula (I) or a stereoisomer, a hydrate, a metabolite, a solvate, a pharmaceutically acceptable salt, an eutectic or a prodrug thereof, and a preparation method thereof, and applications in pre