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863127-77-9

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Dasatinib monohydrate
Cas No: 863127-77-9
No Data 100 Gram 100 Kilogram/Month ShangHai Jin Dun Industrial CO., LTD Contact Supplier
Dasatinib monohydrate with high quality in stock CAS: 863127-77-9
Cas No: 863127-77-9
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mmbfub MMBFUB with powder top quality
Cas No: 863127-77-9
USD $ 1.0-1.0 / Gram 500 Gram 500 Kilogram/Week Hebei Zhuangkai Biotechnology Co.,Ltd Contact Supplier
Dasatinib Monohydrate
Cas No: 863127-77-9
No Data 1 Kilogram 500 Kilogram/Month Huarong Industrial Group Ltd. Contact Supplier
Dasatinib monohydrate
Cas No: 863127-77-9
No Data 10 Gram 50 Kilogram/Month Senova Technology Company Limited Contact Supplier
Dasatinib monohydrate Manufacturer/High quality/Best price/In stock
Cas No: 863127-77-9
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High quality Dasatinib supplier in China
Cas No: 863127-77-9
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
Dasatinib monohydrate 863127-77-9 API
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USD $ 1.0-10.0 / Kilogram 1 Kilogram 5000 Kilogram/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Factory supply high quality Dasatinib monohydrate,863127-77-9
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863127-77-9 Usage

Uses

antineoplastic

Definition

ChEBI: A hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhyd ous dasatinib (INN).

Brand name

Sprycel (Bristol-Myers Squibb).
InChI:InChI=1/C22H27N7O2S2.H2O/c1-14-4-3-5-16(32)20(14)27-21(31)17-13-23-22(33-17)26-18-12-19(25-15(2)24-18)29-8-6-28(7-9-29)10-11-30;/h3-5,12-13,30,32H,6-11H2,1-2H3,(H,27,31)(H,23,24,25,26);1H2

863127-77-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide,hydrate

1.2 Other means of identification

Product number -
Other names UNII-RBZ1571X5H

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:863127-77-9 SDS

863127-77-9Synthetic route

dasatanib
302962-49-8

dasatanib

dasatinib monohydrate
863127-77-9

dasatinib monohydrate

Conditions
ConditionsYield
With ethanol; water at 80℃; for 2h; Large scale;96.44%
With water In ethanol at 75 - 80℃;
With water In ethanol at 0 - 80℃; for 5h;
With water In methanol Solvent; Heating;21 g
N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide
910297-51-7

N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide

2-bromoethanol
540-51-2

2-bromoethanol

dasatinib monohydrate
863127-77-9

dasatinib monohydrate

Conditions
ConditionsYield
With caesium carbonate; potassium iodide In acetonitrile for 6h; Temperature; Solvent; Reagent/catalyst; Reflux;93%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

dasatinib monohydrate
863127-77-9

dasatinib monohydrate

Conditions
ConditionsYield
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In butan-1-ol at 118℃; for 4.5h;
Stage #2: With water In ethanol
83.2%
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; for 2.5h;
Stage #2: With water In N,N-dimethyl-formamide at 20 - 100℃; for 2h;
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-24-5

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

dasatinib monohydrate
863127-77-9

dasatinib monohydrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium t-butanolate / tetrahydrofuran / 10 - 20 °C
1.2: 2 h / 0 - 5 °C / pH 2 - 3
2.1: N-ethyl-N,N-diisopropylamine / pentan-1-ol / 8 h / Reflux
3.1: hydrogenchloride / water / 3 h / 55 - 60 °C
4.1: potassium iodide; caesium carbonate / acetonitrile / 6 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: sodium t-butanolate / tetrahydrofuran / 10 - 20 °C
1.2: 2 h / 0 - 5 °C / pH 2 - 3
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 80 - 85 °C
3.1: sulfuric acid / methanol / 5 h / 5 - 65 °C
4.1: potassium iodide; caesium carbonate / acetonitrile / 6 h / Reflux
View Scheme
[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester
302964-06-3

[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester

dasatinib monohydrate
863127-77-9

dasatinib monohydrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid / 2 h / 25 - 30 °C
2.1: sodium t-butanolate / tetrahydrofuran / 10 - 20 °C
2.2: 2 h / 0 - 5 °C / pH 2 - 3
3.1: N-ethyl-N,N-diisopropylamine / pentan-1-ol / 8 h / Reflux
4.1: hydrogenchloride / water / 3 h / 55 - 60 °C
5.1: potassium iodide; caesium carbonate / acetonitrile / 6 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid / 2 h / 25 - 30 °C
2.1: sodium t-butanolate / tetrahydrofuran / 10 - 20 °C
2.2: 2 h / 0 - 5 °C / pH 2 - 3
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 80 - 85 °C
4.1: sulfuric acid / methanol / 5 h / 5 - 65 °C
5.1: potassium iodide; caesium carbonate / acetonitrile / 6 h / Reflux
View Scheme
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

dasatinib monohydrate
863127-77-9

dasatinib monohydrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 80 - 85 °C
2: sulfuric acid / methanol / 5 h / 5 - 65 °C
3: potassium iodide; caesium carbonate / acetonitrile / 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / pentan-1-ol / 8 h / Reflux
2: hydrogenchloride / water / 3 h / 55 - 60 °C
3: potassium iodide; caesium carbonate / acetonitrile / 6 h / Reflux
View Scheme
dasatinib monohydrate
863127-77-9

dasatinib monohydrate

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
In propan-1-ol; water at 0 - 5℃; for 1h; Product distribution / selectivity; Heating / reflux;
In water; isopropyl alcohol at 0 - 5℃; for 1h; Product distribution / selectivity; Heating / reflux;

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