86318-02-7Relevant academic research and scientific papers
Copper-catalyzed synthesis of 1,2-disubstituted benzimidazoles from imidoyl chlorides
Yu, Hui,Zhang, Mei Shu,Cui, Li Ren
experimental part, p. 573 - 575 (2012/07/14)
A strategy for the synthesis of 1,2-disubstituted benzimidazoles has been developed and a variety of 1,2-disubstituted benzimidazoles were obtained from imidoyl chlorides and o-haloanilines via copper(I)-catalyzed reaction in moderate yields.
Reactivity-controlled regioselectivity: A regiospecific synthesis of 1,2-disubstituted benzimidazoles
Deng, Xiaohu,Mani, Neelakandha S.
experimental part, p. 680 - 686 (2010/03/04)
We demonstrate exceptional levels of regioselectivity in the tandem, animation reactions between 1,2-differentiated dihaloarenes and N-substituted amidines, The regiochemical outcome of this Cul-catalyzed reaction is achieved through a combination of N1/N2 chemoselectivity on the amidine and reactivity-controlled X1/X2 chemoselectivity on the 1,2-dihaloarene. This reaction proves to be fairly general for the regiospecific synthesis of 1,2-substituted benzimidazoles.
1,2 diarylbenzimdazoles and their pharmaceutical use
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, (2008/06/13)
Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
Memory Effects and 1,3-Diazepine Ring Closure in Arylnitrenium Ions
Binding, Norbert,Heesing, Albert
, p. 1822 - 1833 (2007/10/02)
15N- and 18O-Labelling experiments demonstrate that in the aromatic rearrangement of N,N'-diphenyl-N-(4-tosyloxy)benzamidines (2 -> 3 - 6) a strong memory effect occurs in oriented contact ion pairs.The formation of 1,3-diazepines 9 by ring closure betwee
