863297-10-3

Upstream product

• 139210-05-2 (E)-3-(2-Phenyliminomethyleneamino-phenyl)-acrylic acid methyl ester 
• 124-40-3 dimethyl amine 
• 612-41-9 2-nitrocinnamic acid 
• 659748-14-8 methyl 3-[2-(3-phenylureido)phenyl]acrylate 
• 88939-75-7 methyl (2E)-3-(2-aminophenyl)propenoate 
• 39228-29-0 (E)-methyl 2-nitrocinnamate 
• 139210-05-2 methyl 3-[2-(phenyliminomethyleneamino)phenyl]acrylate 

Downstream Products

• 863297-25-0 KYS₀₅₀₅₅ 
• 863297-28-3 KYS₀₅₀₅₆ 
• 863297-18-1 (2-dimethylamino-3-phenyl-3,4-dihydro-quinazolin-4-yl)-acetic acid 

Relevant academic research and scientific papers

Synthesis and SAR studies of a novel series of T-type calcium channel blockers

For the novel, potent, and selective T-type Ca2+ channel blockers, a series of sulfonamido-containing 3,4-dihydroquinazoline derivatives were prepared and evaluated for their blocking actions on T- and N-type Ca2+ channels. Among the

T-type Ca2+ channel blockers suppress the growth of human cancer cells

In order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment.

3,4-Dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same

The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihyd

3,4-Dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same

The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihyd