863301-15-9

Upstream product

• 286441-91-6 toluene-4-sulfonic acid 2-amino-5-methyl-phenyl ester 
• 2835-98-5 2-Hydroxy-4-methylanilin 
• 863301-13-7 4-toluenesulfonic acid 2-amino-3-iodo-5-methylphenyl ester 
• 863301-14-8 2-amino-2'-bromo-5-methyl-3-(4-toluenesulfonyloxy)-1,1'-biphenyl 

Relevant academic research and scientific papers

One-step construction of carbazoles by way of the palladium-catalyzed double N-arylation reaction and its application to the total synthesis of murrastifoline-A

The one-step construction of N-substituted carbazoles by way of the Pd-catalyzed double N-arylation reaction of primary amines with 2,2′-dibromobiphenyl is described. Aryl and aliphatic amines including tert-butylamine and a protected glucopyranosylamine were effectively transformed into the corresponding N-substituted carbazoles. The first total synthesis of murrastifoline-A, a biscarbazole alkaloid, based on this methodology is also presented.

Total synthesis of murrastifoline-A by way of the Pd-catalyzed double N-arylation of a carbazolamine with a 2,2′-dibromobiphenyl derivative

The first total synthesis of murrastifoline-A (1), a biscarbazole alkaloid is described. The biscarbazole skeleton of 1 was effectively constructed by the Pd-catalyzed double N-arylation of carbazolamine (bottom-half segment, 3) with dibromobiphenyl deriv