86334-65-8Relevant academic research and scientific papers
Enantiospecific and Diastereoselective Synthesis of cis Monobactams through Electrophilic Amination of Chiral 3-Hydroxyesters
Banfi, Luca,Cascio, Giuseppe,Guanti, Giuseppe,Manghisi, Elso,Narisano, Enrica,Riva, Renata
, p. 11967 - 11982 (2007/10/02)
A new efficient entry into cis monobactams starting from β-hydroxyesters is reported.This preparation is based on the stereoselective "electrophilic amination" of β-hydroxyester dianions and on Miller's biomimetic synthesis of the β-lactam nucleus.By this route, key intermediates for the preparation of pharmacologically important cis aztreonam 2 and carumonam 3 were prepared.
Optically active β-lactams and method of their production
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, (2008/06/13)
Optically active β-lactams of the general formula STR1 wherein R1 is an amino or protected amino group, R2 is an organic residue bonding through a carbon atom thereof and R3 is the residue remaining after removal of the α-
A STUDY ON THE SYNTHESIS OF CARUMONAM STARTING FROM AN α-AMINO ACID
Hashiguchi, Shohei,Maeda, Yoshiharu,Kishimoto, Shoji,Ochiai, Michihiko
, p. 2273 - 2283 (2007/10/02)
As part of a study on the synthesis of carumonam (1), a method starting from an α-amino acid was investigated.Cycloaddition of the mixed anhydride, derived from carbobenzoxyglycine (7) and isopropyl chloroformate, with the chiral imine (11b), derived from
