99397-29-2

Basic information

• Product Name: (3S,4S)-3-benzyloxycarbonylamino-4-hydroxymethyl-2-azetidinone
• Synonyms: (3S,4S)-3-benzyloxycarbonylamino-4-hydroxymethyl-2-azetidinone
• CAS NO: 99397-29-2
• Molecular Weight: 250.254
• Mol File: 99397-29-2.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: (3S,4S)-3-benzyloxycarbonylamino-4-hydroxymethyl-2-azetidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-3-benzyloxycarbonylamino-4-hydroxymethyl-2-azetidinone(99397-29-2)
• EPA Substance Registry System: (3S,4S)-3-benzyloxycarbonylamino-4-hydroxymethyl-2-azetidinone(99397-29-2)

Safety Data

• Hazardous Substances Data: 99397-29-2(Hazardous Substances Data)

Upstream product

• 108636-63-1 (3S,4S)-3-benzyloxycarbonylamino-1-(1-carboxy-2-methylpropyl)-4-hydroxymethyl-2-azetidinone 
• 108636-63-1 (3S,4S)-3-benzyloxycarbonylamino-1-<(1S)-1-carboxy-1-methylpropyl>-4-hydroxymethyl-2-azetidinone 
• 86334-59-0 benzyl ((2S,3S)-1-(2,4-dimethoxybenzyl)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-oxoazetidin-3-yl)-carbamate 
• 72776-07-9 (S)-4-(hydroxymethyl)-2-azetidinone 
• 501-53-1 benzyl chloroformate 
• 75-65-0 tert-butyl alcohol 
• 126448-46-2 (2S,3S)-3-Benzyloxycarbonylamino-4-oxo-1-((R)-1-phenyl-ethyl)-azetidine-2-carboxylic acid methyl ester 
• 122846-28-0 (3S,4S)-3-<(benzyloxycarbonyl)amino>-4-(tert-butoxycarbonyl)-1-<(R)-1-phenylethyl>-2-azetidinone 
• 108636-61-9 (3S,4S)-3-benzyloxycarbonylamino-4-(p-chlorobenzoyloxymethyl)-1-<(1S)-1-methoxycarbonyl-2-methylpropyl>-2-azetidinone 
• 108636-60-8 3,4-cis-4-benzoyloxymethyl-3-benzyloxycarbonylamino-1-<(1S)-1-methoxycarbonyl-2-methylpropyl>-2-azetidinone 
• 86299-41-4 (3S,4S)-3-(benzyloxycarboxamido)-1-(2,4-dimethoxybenzyl)-4-formyl-2-azetidinone 
• 159622-45-4 (3S,4S) 3-<(benzyloxycarbonyl)amino>-1-(tert-butyldimethylsilyl)-4-<(4-methoxyphenoxy)methyl>-2-azetidinone 
• 159700-63-7 (3S,4S) 3-<(benzyloxycarbonyl)amino>-1-(tert-butyldimethylsilyl)-4-hydroxymethyl-2-azetidinone 
• 86334-63-6 (3S,4S)-3-(benzyloxycarboxamido)-1-(2,4-dimethoxybenzyl)-4-(hydroxymethyl)-2-azetidinone 

Downstream Products

• 113599-60-3 (3S,4S)-3-(benzyloxycarboxamido)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-azetidinone 
• 1380109-66-9 (3S,4S)-3-amino-4-(hydroxymethyl)azetidin-2-one acetic acid 
• 86334-65-8 (3S,4S) 3-<(benzyloxycarbonyl)amino>-4-<(carbamoyloxy)methyl>-2-azetidinone 
• 98675-57-1 (3S,4S)-3-benzyloxycarbonylamino-4-methoxycarbonylazetidin-2-one 
• 84208-16-2 (2S,3S)-3-Benzyloxycarbonylamino-4-oxo-azetidine-2-carboxylic acid 
• 107699-64-9 (3RS,4RS) 3-(<(phenylmethyl)-oxy>-carbonyl)-amino 4-(<(tetrahydropyran-2-yl)-oxy>-methyl) azetidin-2-one 

Relevant articles and documents

MONOBACTAM ORGANIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.

MONOBACTAMS

The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.

Enantiospecific and Diastereoselective Synthesis of cis Monobactams through Electrophilic Amination of Chiral 3-Hydroxyesters

A new efficient entry into cis monobactams starting from β-hydroxyesters is reported.This preparation is based on the stereoselective "electrophilic amination" of β-hydroxyester dianions and on Miller's biomimetic synthesis of the β-lactam nucleus.By this route, key intermediates for the preparation of pharmacologically important cis aztreonam 2 and carumonam 3 were prepared.