86340-76-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 86340-71-8 2-chloro-1-cyclohexyl-2,2-difluoro-1-ethanone 
• 6302-04-1 1-cyclohexyl-2,2,2-trifluoroethanone 

Downstream Products

• 115818-50-3 1-cyclohexyl-2,2-difluoro-3-hydroxy-3-phenyl-1-propanone 

Relevant academic research and scientific papers

Mg0-promoted selective C-F bond cleavage of trifluoromethyl ketones: A convenient method for the synthesis of 2,2-difluoro enol silanes

2,2-difluoro enol silyl ethers were readily prepared by Mg0 promoted selective defluorination of trifluoromethyl ketones in the presence of TMSCI, which involves C-F bond cleavage.

Photoredox-catalyzed redox-neutral difluoroalkylation to construct perfluoroketones with difluoroenoxysilanes

A mild and facile approach to construct various perfluoroketonesviaphoto-catalyzed difluoroalkylation of difluoroenoxysilanes is developed. The reaction includes a strategy of combination of two fluorine-containing functional groups, which confers the reaction with characteristics like high efficiency, mild conditions, and broad scope. A variety of fluoroalkyl halides including perfluoroalkyl iodides, bromo difluoro esters and amides can be employed as radical precursors. Control experiments indicate that a single-electron transfer pathway may be involved in the reaction.

Electroreductive defluorination of trifluoromethyl ketones and trifluoroacetic acid derivatives

Difluoroenol silyl ethers 5 and 6, difluoroketene silyl (O,O-, O,S-, and O,N-) acetals 9 and 21, and 2,2-difluoro-2-trimethylsilylacetates 10 were prepared by electroreductive defluorination of trifluoromethyl ketones and trifluoroacetic acid derivatives in an MeCN-TBAB-chlorotrialkylsilane system using a carbon rod as an anode and a lead plate as a cathode. TBAF- or KF- CuI-promoted α-alkylation of 10 with electrophiles such as aldehydes, ketones, imine, acylhalides, and alkylhalides provided α-alkylated-α,α- difluoroacetates in good to excellent yields.

Preparation of 2,2-difluoroenol silyl ethers by electroreductive defluorination of trifluoromethyl ketones

2,2-Difluoroenol silyl ethers (5) were prepared by electroreductive defluorination of trifluoromethyl ketones (4) in the presence of chlorotrialsilanes (TMSCl, TESCl, TBDMSCl).

A CONVENIENT SYNTHESIS OF 2,2-DIFLUORO ENOL SILYL ETHERS FROM CHLORODIFLUOROMETHYL KETONES

Various chlorodifluoromethyl ketones can be converted to the corresponding 2,2-difluoro enol silyl ethers in good yields, by the action of zinc dust and chlorotrimethylsilane in dry acetonitrile at 60 degC.