863479-40-7

Upstream product

• 871940-23-7 1-ethynyl-3-hydroxy-4-methoxybenzene 
• 274-07-7 benzo[1,3,2]dioxaborole 
• 388566-83-4 1-(3-tert-butyldimethylsilyloxy-4-methoxyphenyl)-2,2-dibromoethene 
• 863479-34-9 3-(tert-butyldimethylsiloxy)-4-methoxyphenylacetylene 

Downstream Products

• 863479-44-1 (1Z,3E)-1-(3',4',5'-trimethoxyphenyl)-4-(3''-hydroxy-4''-methoxyphenyl)-1,3-butadiene 

Relevant academic research and scientific papers

Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives

Stereospecific syntheses of the Z-E and E-Z vinylogues of combretastatin A-4, and two B-ring related analogues, were achieved through a Suzuki-Miyaura coupling. As compared to CA4, the derivative with a phenyl moiety has shown increased potency in its abi