863483-29-8

Upstream product

• 87001-32-9 p-benzyloxybenzenesulfonyl chloride 
• 111712-04-0 4-phenylmethoxybenzenesulfonic acid sodium salt 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 100-39-0 benzyl bromide 
• 863483-28-7 N-((1S,2S)-2-amino-1,2-diphenylethyl)-4-(benzyloxy)benzenesulfonamide 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 863483-31-2 3-[4-((1S,2S)-2-tert-Butoxycarbonylamino-1,2-diphenyl-ethylsulfamoyl)-phenoxy]-propionic acid 
• 863483-30-1 tert-butyl-(1S,2S)-2-(4-hydroxyphenylsulfonamido)-1,2-diphenylethylcarbamate 

Relevant academic research and scientific papers

Asymmetric transfer hydrogenation of ketones with a polyethylene glycol bound Ru catalyst in water

A new polyethylene glycol supported Ru catalyst was synthesized and applied in the asymmetric transfer hydrogenation of various aromatic ketones in water with high chemical yields and enantioselectivities without adding any surfactants. The catalyst could be easily recycled several times without a significant loss of enantioselectivity and activity.

Preparation of polymer-supported Ru-TsDPEN catalysts and use for enantioselective synthesis of (S)-fluoxetine

Polymer-supported chiral ligands 9 and 17 were prepared based on Noyori's (1S,2S)- or (1R,2R)-N-(p-tolylsulfonyl)-1,2-diphenylethylenediamine. The combination with [RuCl2(p-cymene)]2 has been shown to exhibit high activities and enantioselectivities for heterogeneous asymmetric transfer hydrogenation of aromatic ketones (19a-c) with formic acid-triethylamine azeotrope as the hydrogen donor, whereby affording the respective optically active alcohols 20a-c, the key precursors of chiral fluoxetine. As exemplified by ligand 17 for substrate 19c, the catalysts can be recovered and reused in three consecutive runs with no significant decline in enantioselectivity. The procedure avoids the plausible contamination of fluoxetine by the toxic transition metal species. The Royal Society of Chemistry 2005.