86357-17-7

Basic information

• Product Name: 7-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine
• Synonyms: 7-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine
• CAS NO: 86357-17-7
• Molecular Weight: 381.345
• Mol File: 86357-17-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine(86357-17-7)
• EPA Substance Registry System: 7-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine(86357-17-7)

Safety Data

• Hazardous Substances Data: 86357-17-7(Hazardous Substances Data)

Upstream product

• 86357-13-3 2-(acetoxymethoxy)-1,3-propanediyl diacetate 

Downstream Products

• 82410-32-0 ganciclovir 
• 86357-14-4 9-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine 
• 84222-50-4 7-(1,3-dihydroxy-2-propoxymethyl)guanine 

Relevant articles and documents

A facile synthesis of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (ganciclovir) from guanosine

The potent and selective antiviral drug ganciclovir (6) has been synthesized in two steps via transpurination of fully acetylated guanosine (1) in the presence of 1,3-diacetoxy-2-(acetoxymethoxy)propane (2), followed by deacetylation in aqueous ammonia. The transpurination reaction also provides valuable side products, tetra-O-acetyl-β-D-ribofuranose (5) and the 7-regioisomer of triacetylganciclovir (4); the latter product can be converted to the desired 9-isomer in a thermal 7 ? 9 isomerization.