86357-13-3

Basic information

• Product Name: 1,3-Diacetoxy-2-(acetoxymethoxy)propane
• Synonyms: 2-ACETOXYMETHOXY-1,3-DIACETOXY PROPANE;2-ACETOXYMETHOXY-1,3-PROPANEDIOL DIACETATE;Triacetyl Methoxyglycerin;2-ACETOXYMETHOXY-1,3-PROPANEDIOL DIACEETATE;2-ACETOXYMETHOXY-1,3-DIACETOXYPROPANETRIACETYLMETHOXYGLYCERIN;1,3-Diacetoxy-2-(acetoxymethoxy)propane;2-[(Acetyloxy)methoxy]-1,3-propanediol diacetate;Acetic acid,2-acetoxy-1-acetoxyMethyl-ethoxyMethyl ester
• CAS NO: 86357-13-3
• Molecular Formula: C₁₀H₁₆O₇
• Molecular Weight: 248.23
• EINECS: 1592732-453-0
• Product Categories: heterocyclic/Aliphatic series
• Mol File: 86357-13-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 311°C
• Flash Point: 134°C
• Appearance: white crystalline powder
• Density: 1.177
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: 1,3-Diacetoxy-2-(acetoxymethoxy)propane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diacetoxy-2-(acetoxymethoxy)propane(86357-13-3)
• EPA Substance Registry System: 1,3-Diacetoxy-2-(acetoxymethoxy)propane(86357-13-3)

Safety Data

• Hazardous Substances Data: 86357-13-3(Hazardous Substances Data)

Usage

General Description

1,3-Diacetoxy-2-(acetoxymethoxy)propane is a chemical compound with the molecular formula C9H16O6. It is a clear, colorless liquid with a slightly fruity odor and is commonly used as a solvent in various industrial processes. It is also utilized in the production of pharmaceuticals, perfumes, and other chemical compounds. The compound is considered to be moderately hazardous, as it can cause irritation to the skin and eyes upon contact. It is important to handle this chemical with caution and to use appropriate protective equipment when working with it.

InChI:InChI=1/C10H16O7/c1-7(11)14-4-10(5-15-8(2)12)17-6-16-9(3)13/h10H,4-6H2,1-3H3

Upstream product

• 53883-86-6 2-(chloromethoxy)-1,3-dichloropropane 
• 127-08-2 potassium acetate 
• 103824-51-7 2-(methoxymethoxy)-1,3-propanediyl diacetate 
• 70905-45-2 1,3-dichloro-2-(methoxymethoxy)propane 
• 108-24-7 acetic anhydride 
• 127-09-3 sodium acetate 

Downstream Products

• 86357-17-7 7-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine 
• 86357-14-4 9-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine 
• 13035-61-5 1,2,3,5-tetraacetylribose 
• 120398-89-2 RP-170 
• 119552-63-5 Acetic acid 3-acetoxy-2-(2-benzyl-benzoimidazol-1-ylmethoxy)-propyl ester 

Relevant articles and documents

A facile synthesis of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (ganciclovir) from guanosine

The potent and selective antiviral drug ganciclovir (6) has been synthesized in two steps via transpurination of fully acetylated guanosine (1) in the presence of 1,3-diacetoxy-2-(acetoxymethoxy)propane (2), followed by deacetylation in aqueous ammonia. The transpurination reaction also provides valuable side products, tetra-O-acetyl-β-D-ribofuranose (5) and the 7-regioisomer of triacetylganciclovir (4); the latter product can be converted to the desired 9-isomer in a thermal 7 ? 9 isomerization.

Antiviral compounds, treatment and formulations

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Effect of Acyclic Pyrimidines Related to 9-guanine on Herpesviruses

A series of pyrimidines related to the potent antiherpetic agent 9-guanine (1, BW B759U), all containing the same acyclic chain, have been synthesized.Some of the compounds were derivatives of the naturally occuring bases, cytosine, uracil, and thymine; others included compounds in which the 5-position of the cytosine and uracil moieties were substituted by bromo, iodo, fluoro, methyl, and amino groups.Other variations of the cytosine derivatives were the 5-aza, 2-mercapto, 4-methylamino, 4-dimethylamino, and isocytosine congeners.A 4-aminopyrimidine adduct was also made.Antiviral testing showed that 1-cytosine (18, BW A1117U) was equivalent to the guanine analogue in the potency against human cytomegalovirus and Epstein Barr virus.Other compounds in the series were largely inactive in antiviral screening against the herpesviruses.