84222-50-4 Usage
General Description
2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,7-dihydro-6H-purin-6-one, also known as Adenine arabinonucleoside, is a chemical compound that belongs to the class of purine nucleosides. It is a potential antiviral agent that has been studied for its ability to inhibit the replication of human immunodeficiency virus (HIV) and other retroviruses. 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,7-dihydro-6H-purin-6-one has also been investigated for its potential use in the treatment of cancer, as it has been shown to exhibit cytotoxic effects on cancer cells. Additionally, it has been studied for its anti-inflammatory and immunomodulatory properties, making it a promising candidate for the development of new therapeutic agents. Overall, 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,7-dihydro-6H-purin-6-one has shown potential for a wide range of applications in the fields of antiviral, anticancer, anti-inflammatory, and immunomodulatory therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 84222-50-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,2,2 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 84222-50:
(7*8)+(6*4)+(5*2)+(4*2)+(3*2)+(2*5)+(1*0)=114
114 % 10 = 4
So 84222-50-4 is a valid CAS Registry Number.
84222-50-4Relevant articles and documents
A facile synthesis of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (ganciclovir) from guanosine
Boryski, Jerzy,Golankiewicz, Bozenna
, p. 625 - 628 (2007/10/03)
The potent and selective antiviral drug ganciclovir (6) has been synthesized in two steps via transpurination of fully acetylated guanosine (1) in the presence of 1,3-diacetoxy-2-(acetoxymethoxy)propane (2), followed by deacetylation in aqueous ammonia. The transpurination reaction also provides valuable side products, tetra-O-acetyl-β-D-ribofuranose (5) and the 7-regioisomer of triacetylganciclovir (4); the latter product can be converted to the desired 9-isomer in a thermal 7 ? 9 isomerization.
