863641-70-7

Upstream product

• 1383677-77-7 ethyl 3-bromo-1-phenyl-1H-pyrazole-4-carboxylate 
• 191171-55-8 2-anilineboronic acid pinacol ester 
• 508191-77-3 3-phenylsydnone 
• 41658-03-1 ethyl 3-bromoprop-2-ynoate 
• 100-63-0 phenylhydrazine 
• 577-59-3 2-acetylnitrobenzene 
• 863641-59-2 3-(2-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 863641-48-9 3-(2-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 863641-37-6 3-(2-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 107922-63-4 N-[1-(2-nitro-phenyl)-ethylidene]-N'-phenyl-hydrazine 

Downstream Products

• 863641-81-0 4-chloro-2-phenyl-2H-pyrazolo[4,3-c]quinoline 
• 863641-91-2 2-phenyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-thione 
• 863641-82-1 2-phenyl-2H-pyrazolo[4,3-c]quinolin-4-amine 

Relevant academic research and scientific papers

A novel one-pot synthesis of 2-arylpyrazoloquinolinone derivatives

Two regioisomers of 2-arylpyrazolo[3,4-c]quinolin-4(5H)-ones and 2-arylpyrazolo[4,3-c]quinolin-4(5H)-ones were synthesized by utilizing 3-arylsydnones, ethyl 3-bromopropynoate, and 2-aminophenylboronic acid pinacol ester in presence of catalytic agent Pd(PPh3)4. This efficient one-pot synthesis methodology involved 1,3-dipolar cycloaddition, Suzuki coupling reaction, and intramolecular cyclization three sequence steps.

New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists

In this paper we report the synthesis and biological evaluation of a new class of 2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-4-ones as A3 adenosine receptor antagonists. We designed a new route based on the Kira-Vilsmeier reaction for the syn