863767-91-3Relevant academic research and scientific papers
Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity
Deng, Yijun,Wang, Yiqiang,Cherian, Christina,Hou, Zhanjun,Buck, Steven A.,Matherly, Larry H.,Gangjee, Aleem
experimental part, p. 5052 - 5063 (2009/08/07)
6-Substituted classical pyrrolo[2,3-d]pyrimidine antifolates with a three- to six-carbon bridge between the heterocycle and the benzoyl-L-glutamate (compounds 2-5, respectively) were synthesized starting from methyl 4-formylbenzoate and a Wittig reaction
Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates
Gangjee, Aleem,Zeng, Yibin,McGuire, John J.,Kisliuk, Roy L.
, p. 5329 - 5336 (2007/10/03)
We report, for the first time, the biological activities of four-carbon-atom bridged classical antifolates on dihydrofolate reductase (DHFR), thymidylate synthase (TS), and folylpoly-glutamate synthetase (FPGS) as well as antitumor activity. Extension of
