863870-87-5

Basic information

• Product Name: 3-BROMO-2-CHLOROPHENOL
• Synonyms: 3-BROMO-2-CHLOROPHENOL
• CAS NO: 863870-87-5
• Molecular Formula: C₆H₄BrClO
• Molecular Weight: 207.45
• Product Categories: pharmacetical
• Mol File: 863870-87-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 60 °C
• Boiling Point: 246.1 °C at 760 mmHg
• Flash Point: 102.7 °C
• Appearance: /
• Density: 1.788 g/cm³
• Vapor Pressure: 0.0176mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.53±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-2-CHLOROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-CHLOROPHENOL(863870-87-5)
• EPA Substance Registry System: 3-BROMO-2-CHLOROPHENOL(863870-87-5)

Safety Data

• Hazardous Substances Data: 863870-87-5(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-chlorophenol is a chemical compound with the molecular formula C6H4BrClO. It is a white to light yellow crystalline solid with a phenolic odor. 3-Bromo-2-chlorophenol is a halogenated phenol, which is commonly used in the synthesis of various pharmaceuticals, dyes, and agrochemicals. It is also used as an intermediate in the production of other organic compounds. The compound has potential health hazards and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system. It is also harmful if ingested or inhaled.

InChI:InChI=1/C6H4BrClO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H

Upstream product

• 116435-77-9 2-amino-3-bromophenol 
• 591-20-8 3-Bromophenol 
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• 139-66-2 diphenyl sulfide 

Downstream Products

• 1151564-17-8 2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 

Relevant articles and documents

Ammonium Salt-Catalyzed Highly Practical Ortho-Selective Monohalogenation and Phenylselenation of Phenols: Scope and Applications

An ortho-selective ammonium chloride salt-catalyzed direct C-H monohalogenation of phenols and 1,1′-bi-2-naphthol (BINOL) with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as the chlorinating agent has been developed. The catalyst loading was low (down to 0.01 mol %) and the reaction conditions were very mild. A wide range of substrates including BINOLs were compatible with this catalytic protocol. Chlorinated BINOLs are useful synthons for the synthesis of a wide range of unsymmetrical 3-aryl BINOLs that are not easily accessible. In addition, the same catalytic system can facilitate the ortho-selective selenylation of phenols.

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Kinetics and mechanism of chlorination of phenol by N-chloro-3-methyl-2,6-diphenylpiperidin-4-one in acid medium

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