863870-87-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-2-chlorophenol is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Dye Industry:
In the dye industry, 3-Bromo-2-chlorophenol is employed as a precursor in the production of dyes, where its unique chemical structure allows for the creation of a wide range of colorants.
Used in Agrochemical Industry:
3-Bromo-2-chlorophenol is used as a starting material in the formulation of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Organic Compounds Production:
As an intermediate, 3-Bromo-2-chlorophenol is utilized in the production of other organic compounds, playing a crucial role in the synthesis of various chemical entities for different applications.

InChI:InChI=1/C6H4BrClO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H

Upstream product

• 116435-77-9 2-amino-3-bromophenol 
• 863870-72-8 O-3-bromophenyl N,N-diethylcarbamate 
• 95-57-8 2-monochlorophenol 
• 139-66-2 diphenyl sulfide 
• 591-20-8 3-Bromophenol 

Downstream Products

• 872277-20-8 3,4,6-tribromo-2-chloro-phenol 
• 1287791-79-0 N-(3-bromo-2-chlorophenyl)-2-hydroxy-2-methylpropanamide 
• 56131-46-5 3-bromo-2-chlorobenzenamine 
• 1287791-70-1 2-(3-bromo-2-chlorophenoxy)-2-methylpropanamide 
• 1111084-93-5 3-bromo-2-chlorophenyl acetate 
• 1151564-17-8 2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 

Relevant academic research and scientific papers

Ammonium Salt-Catalyzed Highly Practical Ortho-Selective Monohalogenation and Phenylselenation of Phenols: Scope and Applications

An ortho-selective ammonium chloride salt-catalyzed direct C-H monohalogenation of phenols and 1,1′-bi-2-naphthol (BINOL) with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as the chlorinating agent has been developed. The catalyst loading was low (down to 0.01 mol %) and the reaction conditions were very mild. A wide range of substrates including BINOLs were compatible with this catalytic protocol. Chlorinated BINOLs are useful synthons for the synthesis of a wide range of unsymmetrical 3-aryl BINOLs that are not easily accessible. In addition, the same catalytic system can facilitate the ortho-selective selenylation of phenols.

The Catalyst-Controlled Regiodivergent Chlorination of Phenols

Different catalysts are demonstrated to overcome or augment a substrate's innate regioselectivity. Nagasawa's bis-thiourea catalyst was found to overcome the innate para-selectivity of electrophilic phenol chlorination, yielding ortho-chlorinated phenols that are not readily obtainable via canonical electrophilic chlorinations. Conversely, a phosphine sulfide derived from 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) was found to enhance the innate para-preference of phenol chlorination.

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

A new and efficient synthesis of 4-functionalized benzo[6]furans from 2,3-dihalophenols

Tandem Sonogashira coupling/5-endo-dig cyclization reactions on 2,3-dihalophenols suppose a straightforward entry to 4-halobenzo[b]furans, which can be easily transformed into 4-functionalized benzo[b]furans, that are difficult to synthesize by other proc

Process for producing 2-halo-4-bromophenols

A process for the production of 2-halo-4-bromophenols of the formula STR1 in which X represents chlorine or bromine, is disclosed, which process comprises reacting a brominating agent with a 2-halophenol in the presence of a mixed catalyst consisting of a