863886-52-6Relevant academic research and scientific papers
Synthesis of 1-(4-((E)-3-arylacryloyl) phenyl)-3,4-dibromo-1Hpyrrole-2,5- diones and screening for anti-Candida and antituberculosis activity
Patel, J. R.,Dholakiya, B. Z.
, p. 1977 - 1983,7 (2020/07/30)
A series of eleven 1-(4-((E)-3-arylacryloyl) phenyl)-3,4 dibromo-1H-pyrrole-2,5-diones (4′-aminochalcone- based dibromomaleimides) were synthesized using maleic anhydride and p-aminoacetophenone as starting material. Furthermore, there has been some additional work investigating the effect of these derivatives on biological activity. They were characterized using FTIR, 1H NMR, 13C NMR, ESI mass spectroscopy, and elemental analysis. The compounds show anti-Candida & antituberculosis activity.
Development of antiproliferative phenylmaleimides that activate the unfolded protein response
Muus, Ulrike,Hose, Curtis,Yao, Wei,Kosakowska-Cholody, Teresa,Farnsworth, David,Dyba, Marzena,Lountos, George T.,Waugh, David S.,Monks, Anne,Burke Jr., Terrence R.,Michejda, Christopher J.
supporting information; experimental part, p. 4535 - 4541 (2010/08/22)
The current paper presents the synthesis and evaluation of a series of maleimides that were designed to inhibit the Cdc25 phosphatase by alkylation of catalytically essential cysteine residues. Although in HepB3 cell culture assays the analogues did exhib
