86396-55-6

Basic information

• Product Name: methyl 4-(4-chloroanilino)-4-oxobutanoate
• Synonyms: methyl 4-(4-chloroanilino)-4-oxobutanoate;methyl 4-[(4-chlorophenyl)amino]-4-oxobutanoate
• CAS NO: 86396-55-6
• Molecular Formula: C₁₁H₁₂ClNO₃
• Molecular Weight: 241.67088
• Mol File: 86396-55-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 4-(4-chloroanilino)-4-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4-chloroanilino)-4-oxobutanoate(86396-55-6)
• EPA Substance Registry System: methyl 4-(4-chloroanilino)-4-oxobutanoate(86396-55-6)

Safety Data

• Hazardous Substances Data: 86396-55-6(Hazardous Substances Data)

Upstream product

• 3878-55-5 methyl hydrogen succinate 
• 106-47-8 4-chloro-aniline 
• 7242-16-2 N-4-chlorophenyl-maleamic acid 
• 72889-95-3 (Z)-3-(4-Chloro-phenylcarbamoyl)-acrylic acid methyl ester 
• 3052-50-4 monomethyl maleate 
• 67-56-1 methanol 
• 17722-52-0 N-[(4-chlorophenyl)]-4-oxo-4-[oxy]butane amide 

Downstream Products

• 6943-00-6 1-(4-chlorophenyl)pyrrolidine-2,5-dione 

Relevant articles and documents

An expeditious synthesis of imides from phthalic, maleic and succinic anhydrides and chemoselective C=C reduction of maleic amide esters

Phthalic, maleic and succinic anhydrides have been reacted with aromatic amines to obtain the corresponding monoacid monoamides. The latter have been each transformed into the corresponding cyclic imide derivatives by treating with SOCl2. Alternatively, anhydrides have been reacted with methanolic KOH to obtain monomethyl ester derivatives which on reaction with aromatic amines in the presence of EDC. HCl and HOBt give cyclic imide derivatives. Reaction of monoacid monoamides independently, with SOCl 2 at 0-5°C give the monoamide monoester derivatives. Treatment of monoamide monoester of malic anhydride with NaBH4 leads to the unusual reduction of C=C grouping as well as the carbonyl group of the ester group to from monoamide monoalcohol of succinic anhydride. Preparation of monoamide monoalcohol of succinic anhydride can also be achieved by chemoselective reduction of monoamide monoester of malic anhydride with Mg turnings yielding monoamide monoester of succinic anhydride followed by reduction of the latter with NaBH4.

FACILE ESTERIFICATION OF CARBOXYLIC ACIDS WITH ORGANOPHOSPHORUS REAGENTS. NOVEL APPLICATION OF ALKYLPHOSPHORIC ESTERS (APE)

A mixture of alkyl phosphate esters (APE) obtained from P4O10 and alkanols taken in 1:6 mole ratio is an excellent esterification reagent for several classes of carboxylic acids.This new reagent offers several advantages compared to conventional reagents.