86399-83-9Relevant academic research and scientific papers
Antithrombotic agents
-
, (2008/06/13)
This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
N2-aroylanthranilamide inhibitors of human factor Xa
Yee, Ying K.,Tebbe, Anne Louise,Linebarger, Jared H.,Beight, Douglas W.,Craft, Trelia J.,Gifford-Moore, Donetta,Goodson Jr., Theodore,Herron, David K.,Klimkowski, Valentine J.,Kyle, Jeffrey A.,Sawyer, J. Scott,Smith, Gerald F.,Tinsley, Jennifer M.,Towner, Richard D.,Weir, Leonard,Wiley, Michael R.
, p. 873 - 882 (2007/10/03)
Reversal of the A-ring amide link in 1,2-dibenzamidobenzene 1 (fXa K(ass) = 0.81 x 106 L/mol) led to a series of human factor Xa (hfXa) inhibitors based on N2-aroylanthranilamide 4. Expansion of the SAR around 4 showed that only smal
The heterolytic and the homolytic cleavage of the oxygen-nitrogen bond in O,N-diacylarylhydroxylamines
Bassoli, Angela,Gregorio, Giuseppina Di,Galliani, Guido,Riboldi, Massimo,Rindone, Bruno,et al.
, p. 293 - 297 (2007/10/02)
Two O,N-diacylarylhydroxylamines were thermolysed in different solvents and first order rate constants and activation parameters were calculated.A six-membered transition state is suggested in acetonitrile, radical pairs or ion pairs are suggested in the other solvents.Photolysis of five of these compounds gave a homolytic reaction pattern.
