864064-20-0Relevant academic research and scientific papers
Copper-catalyzed enantioselective propargylic substitution of propargylic acetates with enamines
Wang, Bo,Liu, Chunxiao,Guo, Hongchao
, p. 53216 - 53219 (2014)
With the use of chiral tridentate P,N,N ligand, copper-catalyzed enantioselective propargylic substitution of propargylic acetates with enamines has been achieved, giving the corresponding propargylic ketones in high yields and with excellent enantioselec
The β-ketoacid asymmetric synthesis of chiral β-acetylene dimethide method (by machine translation)
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Paragraph 0034; 0035; 0036; 0037; 0038; 0064; 0065, (2017/01/02)
The invention relates to a method for synthesizing chiral beta-acetenyl ketone by catalytic intermolecular decarboxylation from beta-ketonic acid and a propargyl compound. A chiral copper catalyst adopted in the invention is synthesized in stiu from a copper salt and a chiral P,N,N-tridentate ligand in various polar solvents and nonpolar solvents. According to the invention, various chiral beta-acetenyl ketone compounds with substituent groups can be synthesized conveniently, and can obtain a percent enantiomeric excess as high as 95%. The method in the invention is advantaged by operational simplicity, available raw materials, wide substrate application range, high enantioselectivity, and the like.
A chiral β - ethynyl compound of method for catalytic asymmetric synthesis
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Paragraph 0037; 0038; 0039; 0041; 0044; 0047; 0050; 0053, (2018/11/03)
A catalytically asymmetric synthesis method of a chiral [beta]-acetenyl ketone compound. In the method, the chiral [beta]-acetenyl ketone compound is synthesized through an intramolecular asymmetric decarboxylic reaction of a [beta]-ketonic propargyl ester compound with catalysis of a chiral copper catalyst, wherein the chiral copper catalyst is in-situ generated by a copper salt and a chiral P,N,N-tridentate ligand in various polar solvents and nonpolar solvents. The catalytically asymmetric synthesis method can conveniently synthesize various chiral [beta]-acetenyl ketone compounds having substituted groups, of which an enantiomeric excess percentage can reach 98%. The catalytically asymmetric synthesis method is simple in operation. The raw materials are easy to obtain. The synthesis method has a wide substrate application range and a high enantioselectivity.
Enantioselective copper-catalyzed decarboxylative propargylic alkylation of propargyl B-ketoesters with a chiral ketimine P,N,N-ligand
Zhu, Fu-Lin,Zou, Yuan,Zhang, De-Yang,Wang, Ya-Hui,Hu, Xin-Hu,Chen, Song,Xu, Jie,Hu, Xiang-Ping
, p. 1410 - 1414 (2014/03/21)
The first enantioselective copper-catalyzed decarboxylative propargylic alkylation has been developed. Treatment of propargyl b-ketoesters with a catalyst, prepared in situ from [Cu(CH3CN)4BF4] and a newly developed chiral tridentate ketimine P,N,N-ligand
