864066-74-0

Usage

Uses

Used in Polymer Synthesis Industry:
RAFT polymerization agent is used as a chain transfer agent for controlled radical polymerization, enabling the synthesis of polymers with precise molecular weights, narrow molecular weight distributions, and well-defined architectures.
Used in Pharmaceutical Industry:
RAFT polymerization agent is used as a tool for the synthesis of biocompatible and biodegradable polymers, which have potential applications in drug delivery systems, tissue engineering, and regenerative medicine.
Used in Material Science Industry:
RAFT polymerization agent is used for the development of novel materials with tailored properties, such as stimuli-responsive polymers, block copolymers, and polymer brushes, which can be applied in various fields including sensors, coatings, and nanotechnology.
Used in Chemical Industry:
RAFT polymerization agent is used for the synthesis of functional polymers with specific chemical groups, which can be employed in catalysis, separation processes, and other chemical applications.

Upstream product

• 2638-94-0 4,4'-dicyano-4,4'-azo-di-valeric acid 
• 121-68-6 dithiobenzoic acid 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 201611-92-9 4-cyano-4-(thiobenzoylthio)pentanoic acid 

Downstream Products

• 864066-75-1 C₁₄₄H₁₈₄N₂₂O₈S₁₆ 

Relevant academic research and scientific papers

Fabrication of Reductive-Responsive Prodrug Nanoparticles with Superior Structural Stability by Polymerization-Induced Self-Assembly and Functional Nanoscopic Platform for Drug Delivery

A highly efficient strategy, polymerization-induced self-assembly (PISA) for fabrication of the polymeric drug delivery systems in cancer chemotherapy is reported. Diblock prodrug copolymer, PEG-b-P(MEO2MA-co-CPTM) was used as the macro-RAFT ag

RAFT aqueous dispersion polymerization yields poly(ethylene glycol)-based diblock copolymer nano-objects with predictable single phase morphologies

A poly(ethylene glycol) (PEG) macromolecular chain transfer agent (macro-CTA) is prepared in high yield (>95%) with 97% dithiobenzoate chain-end functionality in a three-step synthesis starting from a monohydroxy PEG113 precursor. This PEG

Synthesis of cationic N-[3-(dimethylamino)propyl]methacrylamide brushes on silicon wafer via surface-initiated RAFT polymerization

Surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization of N-[3-(dimethylamino)propyl]methacrylamide (DMAPMA) on the silicon wafer was conducted in attempt to create controllable cationic polymer films. The RAFT agent-i

Polyethylene building blocks by catalyzed chain growth and efficient end functionalization strategies, including click chemistry

(Chemical Equation Presented) A means to an end: Polyethylene chains obtained by catalyzed chain growth on magnesium and exhibiting molar masses up to 5000 g mol-1 have been end-functionalized in high yield with iodide, azide, and amine reactiv

ANTIBODY-POLYMER-CONJUGATES

The present invention relates to antibody-polymer conjugates which have high drug carrying capacity and which can realize active targeting thanks to the antibody existing thereon.

DNA-Polymer Conjugates by Photoinduced RAFT Polymerization

Conventional grafting-to approaches to DNA-polymer conjugates are often limited by low reaction yields due to the sterically hindered coupling of a presynthesized polymer to DNA. The grafting-from strategy, in contrast, allows one to directly graft polymers from an initiator that is covalently attached to DNA. Herein, we report blue-light-mediated reversible addition-fragmentation chain-transfer (Photo-RAFT) polymerization from two different RAFT agent-terminated DNA sequences using Eosin Y as the photocatalyst in combination with ascorbic acid. Three monomer families (methacrylates, acrylates and acrylamides) were successfully polymerized from DNA employing Photo-RAFT polymerization. We demonstrate that the length of the grown polymer chain can be varied by altering the monomer to DNA-initiator ratio, while the self-assembly features of the DNA strands were maintained. In summary, we describe a convenient, light-mediated approach toward DNA-polymer conjugates via the grafting-from approach.

A switchable polymer brush system for antifouling and controlled detection

A stimuli-responsive polymer brush system is designed to switch on and off surface functionality and prevent functional groups from fouling by grafting together two polymer brushes with precisely controlled lengths. The polymer brush with functional group

Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen-Bonding Junctions

We designed efficient precursors that combine complementary associative groups with exceptional binding affinities and thiocarbonylthio moieties enabling precise RAFT polymerization. Well defined PS and PMMA supramolecular polymers with molecular weights up to 30 kg mol?1are synthesized and shown to form highly stable supramolecular diblock copolymers (BCPs) when mixed, in non-polar solvents or in the bulk. Hierarchical self-assembly of such supramolecular BCPs by thermal annealing affords morphologies with excellent lateral order, comparable to features expected from covalent diblock copolymer analogues. Simple washing of the resulting materials with protic solvents disrupts the supramolecular association and selectively dissolves one polymer, affording a straightforward process for preparing well-ordered nanoporous materials without resorting to crosslinking or invasive chemical degradations.

Versatile precursors of functional RAFT agents. Application to the synthesis of bio-related end-functionalized polymers

Biomolecule-polymer conjugates are widely used in bio-related fields, but their synthesis is often tricky, especially the introduction of a single biomolecule at one chain end. This paper describes a new straightforward approach to prepare such conjugates

Synthesis and characterization of dendrimer-star polymer using dithiobenzoate-terminated poly(propylene imine) dendrimer via reversible addition-fragmentation transfer polymerization

Two new reversible addition-fragmentation transfer (RAFT) agents with 8 and 16 terminal dithiobenzoate groups on the surface of poly(propylene imine) dendrimers (generation 2.0 and 3.0, respectively) were prepared, and successively they were used in the RAFT polymerization to produce well-defined dendrimer-star polymers. The polymerization kinetics were confirmed to pseudo-first-order behavior. The polymerizations displayed excellent molecular weight control and produced polymer with low polydispersities (1.3). The synthetic method was also suitable for the preparation of dendrimerstar block copolymers.