201611-92-9Relevant articles and documents
Visible-light degradable polymer coated hollow mesoporous silica nanoparticles for controlled drug release and cell imaging
Yang, Shun,Li, Najun,Chen, Dongyun,Qi, Xiuxiu,Xu, Yujie,Xu, Ying,Xu, Qingfeng,Li, Hua,Lu, Jianmei
, p. 4628 - 4636 (2013)
A core-shell nanocomposite based on photo-degradable polymer coated hollow mesoporous silica nanoparticles (HMS) was successfully prepared for targeted drug delivery and visible-light triggered release, as well as fluorescence cell imaging. The HMS nanoparticles were first modified by the long-chain hydrocarbon octadecyltrimethoxysilane (C18) and fluorescent agent Rhodamine B isothiocyanate (RITC), and then encapsulated by a photodegradable amphiphilic copolymer via a self-assembly process. The obtained nanocarrier showed a high drug loading content due to the hollow core and mesopores of the HMS and could target folic acid receptor over-expressed tumor cells efficiently for conjugating folic acid (FA) in the amphiphilic polymer. The drug release could be triggered by the irradiation of green light (500-540 nm) due to the photodegradation of amphiphilic copolymer coated on the HMS. Furthermore, the targeted drug delivery and controlled release processes could be tracked by fluorescence imaging for the doping of RITC on the HMS. The In vitro results suggested that a smart visible light responsive drug delivery system was successfully prepared for the potential applications of cancer diagnosis and therapy.
Fine-tuning the transition temperature of a stimuli-responsive polymer by a simple blending procedure
Fernandez-Trillo, Francisco,Van Hest, Jan C. M.,Thies, Jens C.,Michon, Thierry,Weberskirch, Ralf,Cameron, Neil R.
, p. 2230 - 2232 (2008)
Binary mixtures of well-defined, stimuli-responsive elastin-based side-chain polymers show a single transition temperature that depends on blend composition. The Royal Society of Chemistry.
Visible-Light-Driven MADIX Polymerisation via a Reusable, Low-Cost, and Non-Toxic Bismuth Oxide Photocatalyst
Hakobyan, Karen,Gegenhuber, Thomas,McErlean, Christopher S. P.,Müllner, Markus
supporting information, p. 1828 - 1832 (2019/01/14)
The continuous amalgamation of photocatalysis into existing reversible deactivation radical polymerisation (RDRP) processes has initiated a rapidly propagating area of polymer research in recent years. We introduce bismuth oxide (Bi2O3) as a heterogeneous photocatalyst for polymerisations, operating at room temperature with visible light. We demonstrate formidable control over degenerative chain-transfer polymerisations, such as macromolecular design by interchange of xanthate (MADIX) and reversible addition-fragmentation chain-transfer (RAFT) polymerisation. We achieved narrow molecular weight distributions and attribute the excellent temporal control of a photo-induced electron transfer (PET) process. This methodology was employed to synthesise diblock copolymers combining differently activated monomers. The Bi2O3 catalyst system has the additional benefits of low toxicity, reusability, low-cost, and ease of removal from the reaction mixture.
Coumarin-containing photo-responsive nanocomposites for NIR light-triggered controlled drug release via a two-photon process
Ji, Weidong,Li, Najun,Chen, Dongyun,Qi, Xiuxiu,Sha, Wenwei,Jiao, Yang,Xu, Qingfeng,Lu, Jianmei
supporting information, p. 5942 - 5949 (2013/11/19)
A new multifunctional nanovehicle for tumor therapy and cell imaging was fabricated by coating NIR light-responsive polymers (HAMAFA-b-DDACMM) onto the surface of octadecyltrimethoxysilane (C18)-modified hollow mesoporous silica nanoparticles (HMS@C18) via self-assembly. First, the targeting NIR light-responsive block copolymer was synthesized by the RAFT living polymerization of [7-(didodecylamino) coumarin-4-yl] methyl methacrylate with hydroxyethylacrylate and N-(3-aminopropyl) methacrylamide hydrochloride and then grafted with folic acid (FA). The copolymers could be disrupted by excitation by a femtosecond NIR light laser (800 nm) via a two-photon absorption process due to the high two-photon absorption cross-section of the coumarin moiety. In order to enhance the drug loading capacity and biological stability of the nanovehicle, HMS nanoparticles modified by hydrophobic octadecyl chains were selected as the "core", which had a considerable drug loading efficiency of more than 70%. Then the core-shell nanocomposites (HMS@C18@HAMAFA-b-DDACMM) were obtained by coating the amphiphilic copolymers onto the core via self-assembly. Under excitation by NIR light at 800 nm, the pre-loaded drugs could be released from the nanocomposites due to the degradation of the light-responsive copolymers and the release efficiency was correlated with the irradiation time and light power. The in vitro experiments indicated that the nanocomposites were easily targeted into the tumor cells that over-expressed folic acid receptor (FR(+)) such as KB cells by endocytosis. Furthermore, the copolymer itself had strong fluorescence, which could be used to track the process of drug delivery.
